Self-microemulsifying drug delivery systems of Moringa oleifera extract for enhanced dissolution of kaempferol and quercetin
The aim of the present study was to develop self-microemulsifying drug delivery systems (SMEDDS) of the extract of Moringa oleifera, a herbal medicinal plant. Kaempferol and quercetin, the flavonoids present in the leaf extract of M. oleifera, were chosen as markers for quantification. The optimized...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2020-03-01
|
| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2020-0012 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832570590273208320 |
|---|---|
| author | Sermkaew Namfa Plyduang Thipapun |
| author_facet | Sermkaew Namfa Plyduang Thipapun |
| author_sort | Sermkaew Namfa |
| collection | DOAJ |
| description | The aim of the present study was to develop self-microemulsifying drug delivery systems (SMEDDS) of the extract of Moringa oleifera, a herbal medicinal plant. Kaempferol and quercetin, the flavonoids present in the leaf extract of M. oleifera, were chosen as markers for quantification. The optimized formulation of SMEDDS consisted of propylene glycol dicaprylocaprate, polysorbate 80, and polyethylene glycol 400 (PEG 400) in a percentage ratio of 20:60:20 (m/m). SMEDDS emulsified immediately (within 20 s) after dilution in water, resulting in transparent microemulsions with a droplet size of 49 nm. SMEDDS could increase the solubility of kaempferol and quercetin to nearly 100 % within 15 min, whereas only a 30 % improvement in solubility was achieved in the case of crude extract. These results demonstrated SMEDDS to be a promising strategy to improve the solubility of M. oleifera extract-derived drugs, which, in turn, could prove beneficial to the herbal medicine field. |
| format | Article |
| id | doaj-art-c8a16e23334149d58470dd8aad7abfa9 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-c8a16e23334149d58470dd8aad7abfa92025-02-02T15:05:35ZengSciendoActa Pharmaceutica1846-95582020-03-01701778810.2478/acph-2020-0012acph-2020-0012Self-microemulsifying drug delivery systems of Moringa oleifera extract for enhanced dissolution of kaempferol and quercetinSermkaew Namfa0Plyduang Thipapun1School of Pharmacy, Walailak University, Nakhon Si Thammarat, 80161, ThailandSchool of Pharmacy, Walailak University, Nakhon Si Thammarat, 80161, ThailandThe aim of the present study was to develop self-microemulsifying drug delivery systems (SMEDDS) of the extract of Moringa oleifera, a herbal medicinal plant. Kaempferol and quercetin, the flavonoids present in the leaf extract of M. oleifera, were chosen as markers for quantification. The optimized formulation of SMEDDS consisted of propylene glycol dicaprylocaprate, polysorbate 80, and polyethylene glycol 400 (PEG 400) in a percentage ratio of 20:60:20 (m/m). SMEDDS emulsified immediately (within 20 s) after dilution in water, resulting in transparent microemulsions with a droplet size of 49 nm. SMEDDS could increase the solubility of kaempferol and quercetin to nearly 100 % within 15 min, whereas only a 30 % improvement in solubility was achieved in the case of crude extract. These results demonstrated SMEDDS to be a promising strategy to improve the solubility of M. oleifera extract-derived drugs, which, in turn, could prove beneficial to the herbal medicine field.https://doi.org/10.2478/acph-2020-0012moringa oleiferaself-microemulsifyingcrude extractkaempferolquercetin |
| spellingShingle | Sermkaew Namfa Plyduang Thipapun Self-microemulsifying drug delivery systems of Moringa oleifera extract for enhanced dissolution of kaempferol and quercetin Acta Pharmaceutica moringa oleifera self-microemulsifying crude extract kaempferol quercetin |
| title | Self-microemulsifying drug delivery systems of Moringa oleifera extract for enhanced dissolution of kaempferol and quercetin |
| title_full | Self-microemulsifying drug delivery systems of Moringa oleifera extract for enhanced dissolution of kaempferol and quercetin |
| title_fullStr | Self-microemulsifying drug delivery systems of Moringa oleifera extract for enhanced dissolution of kaempferol and quercetin |
| title_full_unstemmed | Self-microemulsifying drug delivery systems of Moringa oleifera extract for enhanced dissolution of kaempferol and quercetin |
| title_short | Self-microemulsifying drug delivery systems of Moringa oleifera extract for enhanced dissolution of kaempferol and quercetin |
| title_sort | self microemulsifying drug delivery systems of moringa oleifera extract for enhanced dissolution of kaempferol and quercetin |
| topic | moringa oleifera self-microemulsifying crude extract kaempferol quercetin |
| url | https://doi.org/10.2478/acph-2020-0012 |
| work_keys_str_mv | AT sermkaewnamfa selfmicroemulsifyingdrugdeliverysystemsofmoringaoleiferaextractforenhanceddissolutionofkaempferolandquercetin AT plyduangthipapun selfmicroemulsifyingdrugdeliverysystemsofmoringaoleiferaextractforenhanceddissolutionofkaempferolandquercetin |