Circulating Biomarkers in Lower Extremity Artery Disease
Lower extremity artery disease (LEAD), a chronic condition with disturbed lower extremity circulation due to narrowing of the arteries, is predominantly caused by atherosclerosis and is associated with the presence of cardiovascular risk factors and an increased risk of cardiovascular events. LEAD i...
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| Format: | Article |
| Language: | English |
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Radcliffe Medical Media
2022-03-01
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| Series: | European Cardiology Review |
| Online Access: | https://www.ecrjournal.com/articleindex/ecr.2021.58 |
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| _version_ | 1850256229365972992 |
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| author | Louise Ziegler Ulf Hedin Anders Gottsäter |
| author_facet | Louise Ziegler Ulf Hedin Anders Gottsäter |
| author_sort | Louise Ziegler |
| collection | DOAJ |
| description | Lower extremity artery disease (LEAD), a chronic condition with disturbed lower extremity circulation due to narrowing of the arteries, is predominantly caused by atherosclerosis and is associated with the presence of cardiovascular risk factors and an increased risk of cardiovascular events. LEAD is prevalent among older individuals and predicted to rise with the ageing population. In progressive disease, the patient experiences symptoms of ischaemia when walking and, in advanced critical limb-threatening ischaemia, even at rest. However, LEAD is asymptomatic in most patients, delaying diagnosis and treatment. In this setting, circulating biomarkers may facilitate earlier diagnosis in selected individuals. This review provides a broad overview of the circulating biomarkers investigated to date in relation to LEAD and discusses their usefulness in clinical practice. |
| format | Article |
| id | doaj-art-c89f5ebb71f34bfc865c47e9834642d5 |
| institution | OA Journals |
| issn | 1758-3756 1758-3764 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | European Cardiology Review |
| spelling | doaj-art-c89f5ebb71f34bfc865c47e9834642d52025-08-20T01:56:41ZengRadcliffe Medical MediaEuropean Cardiology Review1758-37561758-37642022-03-011710.15420/ecr.2021.58Circulating Biomarkers in Lower Extremity Artery DiseaseLouise Ziegler0Ulf Hedin1Anders Gottsäter2Division of Internal Medicine, Department of Clinical Sciences, Karolinska Institute, Danderyd Hospital, Stockholm, SwedenVascular Surgery Division, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, SwedenDepartment of Medicine, Lund University, Malmö, Sweden; Department of Medicine, Skåne University Hospital, Malmö, SwedenLower extremity artery disease (LEAD), a chronic condition with disturbed lower extremity circulation due to narrowing of the arteries, is predominantly caused by atherosclerosis and is associated with the presence of cardiovascular risk factors and an increased risk of cardiovascular events. LEAD is prevalent among older individuals and predicted to rise with the ageing population. In progressive disease, the patient experiences symptoms of ischaemia when walking and, in advanced critical limb-threatening ischaemia, even at rest. However, LEAD is asymptomatic in most patients, delaying diagnosis and treatment. In this setting, circulating biomarkers may facilitate earlier diagnosis in selected individuals. This review provides a broad overview of the circulating biomarkers investigated to date in relation to LEAD and discusses their usefulness in clinical practice.https://www.ecrjournal.com/articleindex/ecr.2021.58 |
| spellingShingle | Louise Ziegler Ulf Hedin Anders Gottsäter Circulating Biomarkers in Lower Extremity Artery Disease European Cardiology Review |
| title | Circulating Biomarkers in Lower Extremity Artery Disease |
| title_full | Circulating Biomarkers in Lower Extremity Artery Disease |
| title_fullStr | Circulating Biomarkers in Lower Extremity Artery Disease |
| title_full_unstemmed | Circulating Biomarkers in Lower Extremity Artery Disease |
| title_short | Circulating Biomarkers in Lower Extremity Artery Disease |
| title_sort | circulating biomarkers in lower extremity artery disease |
| url | https://www.ecrjournal.com/articleindex/ecr.2021.58 |
| work_keys_str_mv | AT louiseziegler circulatingbiomarkersinlowerextremityarterydisease AT ulfhedin circulatingbiomarkersinlowerextremityarterydisease AT andersgottsater circulatingbiomarkersinlowerextremityarterydisease |