Repurposing AZD-5991 for inhibiting growth and biofilm formation of Staphylococcus aureus by disrupting the cell membrane and targeting FabI

Repurposing AZD-5991 for inhibiting growth and biofilm formation of Staphylococcus aureus by disrupting the cell membrane and targeting FabI

Abstract Staphylococcus aureus infections have emerged as a global public health threat. Two key factors—drug resistance and biofilm formation—substantially impair the efficacy of the antimicrobial treatment for S. aureus infections using conventional antibiotics. Consequently, discovering novel ant...

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Bibliographic Details
Main Authors: Yuanyuan Tang, Han Deng, Zhichao Xu, Zhijian Yu, Yong Xiang, Zewen Wen, Shiqing Han, Zhong Chen, Tieying Hou
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Microbiology
Subjects:
Staphylococcus aureus
Antimicrobial activity
AZD-5991
Biofilm
FabI
Online Access:https://doi.org/10.1186/s12866-025-04104-2
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https://doi.org/10.1186/s12866-025-04104-2

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