Integrating antigen capturing nanoparticles and type 1 conventional dendritic cell therapy for in situ cancer immunization

Integrating antigen capturing nanoparticles and type 1 conventional dendritic cell therapy for in situ cancer immunization

Abstract Eliciting a robust immune response against tumors is often hampered by the inadequate presence of effective antigen presenting cells and their suboptimal ability to present antigens within the immunosuppressive tumor microenvironment. Here, we report a cascade antigen relay strategy integra...

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Main Authors: Chih-Jia Chao, Endong Zhang, Duong N. Trinh, Edidiong Udofa, Hanchen Lin, Caylee Silvers, Jiawei Huo, Shan He, Jingtian Zheng, Xiaoying Cai, Qing Bao, Luyu Zhang, Philana Phan, Sara M. Elgendy, Xiangqian Shi, Joanna E. Burdette, Steve Seung-Young Lee, Yu Gao, Peng Zhang, Zongmin Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59840-w
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https://doi.org/10.1038/s41467-025-59840-w

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