Comparison of baseline patient characteristics in phase 1 and phase 2/3 clinical trials for anticancer treatments

Comparison of baseline patient characteristics in phase 1 and phase 2/3 clinical trials for anticancer treatments

Abstract Background Characteristics of patients significantly differ between registrational clinical trials (CTs) and Italian real-world practice, with older median age, higher elderly (≥ 65) rate and worse performance status (PS) in the latter, without imbalance in female rate. We compared the same...

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Main Authors: Maria Lucia Iacovino, Simone Talucci, Laura Arenare, Andrea Caglio, Andrea Canciello, Flavio Salerno, Sergio Facchini, Adriano Gravina, Clorinda Schettino, Maria Carmela Piccirillo, Pier Paolo Olimpieri, Massimo Di Maio, Francesco Perrone
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Clinical trials
Phase 1
Age
Sex
Performance status
Online Access:https://doi.org/10.1186/s12967-025-06509-z
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