Early introduction of IL-10 weakens BCG revaccination’s protection by suppressing CD4+Th1 cell responses

Abstract Background The Bacillus Calmette-Guérin (BCG) vaccine, currently the sole authorized vaccine against tuberculosis (TB), demonstrates limited effectiveness in safeguarding adolescents and adults from active TB, even when administered as a booster with either BCG itself or heterologous vaccin...

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Bibliographic Details
Main Authors:	Qing Lei, Hui Fu, Zongjie Yao, Zijie Zhou, Yueqing Wang, Xiaosong Lin, Yin Yuan, Qi Ouyang, Xinyue Xu, Jinge Cao, Mengze Gan, Xionglin Fan
Format:	Article
Language:	English
Published:	BMC 2024-12-01
Series:	Journal of Translational Medicine
Subjects:	BCG revaccination BCG prime-boost strategy Adult tuberculosis Primary Mycobacterium tuberculosis infection IL-10 inhibition Memory CD4+ T cell
Online Access:	https://doi.org/10.1186/s12967-024-05683-w
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Early introduction of IL-10 weakens BCG revaccination’s protection by suppressing CD4+Th1 cell responses

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