Early introduction of IL-10 weakens BCG revaccination’s protection by suppressing CD4+Th1 cell responses

Early introduction of IL-10 weakens BCG revaccination’s protection by suppressing CD4+Th1 cell responses

Abstract Background The Bacillus Calmette-Guérin (BCG) vaccine, currently the sole authorized vaccine against tuberculosis (TB), demonstrates limited effectiveness in safeguarding adolescents and adults from active TB, even when administered as a booster with either BCG itself or heterologous vaccin...

Full description

Saved in:
Bibliographic Details
Main Authors: Qing Lei, Hui Fu, Zongjie Yao, Zijie Zhou, Yueqing Wang, Xiaosong Lin, Yin Yuan, Qi Ouyang, Xinyue Xu, Jinge Cao, Mengze Gan, Xionglin Fan
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
BCG revaccination
BCG prime-boost strategy
Adult tuberculosis
Primary Mycobacterium tuberculosis infection
IL-10 inhibition
Memory CD4+ T cell
Online Access:https://doi.org/10.1186/s12967-024-05683-w
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12967-024-05683-w

Similar Items