Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection.

Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection.

Select prion diseases are characterized by widespread cerebral plaque-like deposits of amyloid fibrils enriched in heparan sulfate (HS), a abundant extracellular matrix component. HS facilitates fibril formation in vitro, yet how HS impacts fibrillar plaque growth within the brain is unclear. Here w...

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Main Authors: Patricia Aguilar-Calvo, Adela Malik, Daniel R Sandoval, Christopher Barback, Christina D Orrù, Heidi G Standke, Olivia R Thomas, Chrissa A Dwyer, Donald P Pizzo, Jaidev Bapat, Katrin Soldau, Ryotaro Ogawa, Mckenzie B Riley, K Peter R Nilsson, Allison Kraus, Byron Caughey, Jeffrey J Iliff, David R Vera, Jeffrey D Esko, Christina J Sigurdson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-09-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011487&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011487&type=printable

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