Controlled Release of Hydrophilic Active Agent from Textile Using Crosslinked Polyvinyl Alcohol Coatings
Functional fabrics embedded with active materials that can be released in a controlled manner upon external triggering have been explored for biomedical and cosmetic applications. This study introduces a method for the fabrication of nonwoven fabrics coated with crosslinked polyvinyl alcohol (PVA) f...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/16/6/216 |
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| author | Limor Mizrahi Rotem Kelman Efrat Shtriker David Meridor Dror Cohen Meital Portugal-Cohen Elizabeth Amir |
| author_facet | Limor Mizrahi Rotem Kelman Efrat Shtriker David Meridor Dror Cohen Meital Portugal-Cohen Elizabeth Amir |
| author_sort | Limor Mizrahi |
| collection | DOAJ |
| description | Functional fabrics embedded with active materials that can be released in a controlled manner upon external triggering have been explored for biomedical and cosmetic applications. This study introduces a method for the fabrication of nonwoven fabrics coated with crosslinked polyvinyl alcohol (PVA) for in situ encapsulation and controlled release of hydrophilic active agent, allantoin. Two types of crosslinked coatings were examined using citric acid (CA) or polyacrylic acid (PAA) as crosslinkers. Based on gel content, differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) analyses PVA:CA coatings exhibited a higher crosslinking density compared to PVA:PAA systems. Swelling behavior was measured at 62% after 30 min for PVA:PAA 7:3 films and 36% after 60 min for PVA:CA 7:3 crosslinked films. The release of allantoin from the coated fabrics was influenced by the coating thickness (250–330 µm), the formulation viscosity (8–250 cP), allantoin content (1.2–4.2 mg) and the molecular weight between crosslinks (M<sub>C</sub>) 1,000,000–494 g/mol. PVA:CA 7:3 coating allowed the controlled release of 97% allantoin over 8 h, whereas PVA:PAA 7:3 coating exhibited a more prolonged release profile, with 96% of allantoin released over 20 h. Kinetic analyses of the release profiles revealed a good agreement with zero-order release. |
| format | Article |
| id | doaj-art-c83d9b5d2bd947c69f2b03cdfa988b6c |
| institution | OA Journals |
| issn | 2079-4983 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Journal of Functional Biomaterials |
| spelling | doaj-art-c83d9b5d2bd947c69f2b03cdfa988b6c2025-08-20T02:20:58ZengMDPI AGJournal of Functional Biomaterials2079-49832025-06-0116621610.3390/jfb16060216Controlled Release of Hydrophilic Active Agent from Textile Using Crosslinked Polyvinyl Alcohol CoatingsLimor Mizrahi0Rotem Kelman1Efrat Shtriker2David Meridor3Dror Cohen4Meital Portugal-Cohen5Elizabeth Amir6Department of Polymer Materials Engineering, Shenkar College, Ramat-Gan 5252626, IsraelDepartment of Polymer Materials Engineering, Shenkar College, Ramat-Gan 5252626, IsraelDepartment of Polymer Materials Engineering, Shenkar College, Ramat-Gan 5252626, IsraelDepartment of Polymer Materials Engineering, Shenkar College, Ramat-Gan 5252626, IsraelAHAVA Dead Sea Laboratories Ltd., 1 Arava, Airport City 7019900, IsraelAHAVA Dead Sea Laboratories Ltd., 1 Arava, Airport City 7019900, IsraelDepartment of Polymer Materials Engineering, Shenkar College, Ramat-Gan 5252626, IsraelFunctional fabrics embedded with active materials that can be released in a controlled manner upon external triggering have been explored for biomedical and cosmetic applications. This study introduces a method for the fabrication of nonwoven fabrics coated with crosslinked polyvinyl alcohol (PVA) for in situ encapsulation and controlled release of hydrophilic active agent, allantoin. Two types of crosslinked coatings were examined using citric acid (CA) or polyacrylic acid (PAA) as crosslinkers. Based on gel content, differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) analyses PVA:CA coatings exhibited a higher crosslinking density compared to PVA:PAA systems. Swelling behavior was measured at 62% after 30 min for PVA:PAA 7:3 films and 36% after 60 min for PVA:CA 7:3 crosslinked films. The release of allantoin from the coated fabrics was influenced by the coating thickness (250–330 µm), the formulation viscosity (8–250 cP), allantoin content (1.2–4.2 mg) and the molecular weight between crosslinks (M<sub>C</sub>) 1,000,000–494 g/mol. PVA:CA 7:3 coating allowed the controlled release of 97% allantoin over 8 h, whereas PVA:PAA 7:3 coating exhibited a more prolonged release profile, with 96% of allantoin released over 20 h. Kinetic analyses of the release profiles revealed a good agreement with zero-order release.https://www.mdpi.com/2079-4983/16/6/216polyvinyl alcoholsustained releaseallantoinnonwoven fabricpolyacrylic acidcoating |
| spellingShingle | Limor Mizrahi Rotem Kelman Efrat Shtriker David Meridor Dror Cohen Meital Portugal-Cohen Elizabeth Amir Controlled Release of Hydrophilic Active Agent from Textile Using Crosslinked Polyvinyl Alcohol Coatings Journal of Functional Biomaterials polyvinyl alcohol sustained release allantoin nonwoven fabric polyacrylic acid coating |
| title | Controlled Release of Hydrophilic Active Agent from Textile Using Crosslinked Polyvinyl Alcohol Coatings |
| title_full | Controlled Release of Hydrophilic Active Agent from Textile Using Crosslinked Polyvinyl Alcohol Coatings |
| title_fullStr | Controlled Release of Hydrophilic Active Agent from Textile Using Crosslinked Polyvinyl Alcohol Coatings |
| title_full_unstemmed | Controlled Release of Hydrophilic Active Agent from Textile Using Crosslinked Polyvinyl Alcohol Coatings |
| title_short | Controlled Release of Hydrophilic Active Agent from Textile Using Crosslinked Polyvinyl Alcohol Coatings |
| title_sort | controlled release of hydrophilic active agent from textile using crosslinked polyvinyl alcohol coatings |
| topic | polyvinyl alcohol sustained release allantoin nonwoven fabric polyacrylic acid coating |
| url | https://www.mdpi.com/2079-4983/16/6/216 |
| work_keys_str_mv | AT limormizrahi controlledreleaseofhydrophilicactiveagentfromtextileusingcrosslinkedpolyvinylalcoholcoatings AT rotemkelman controlledreleaseofhydrophilicactiveagentfromtextileusingcrosslinkedpolyvinylalcoholcoatings AT efratshtriker controlledreleaseofhydrophilicactiveagentfromtextileusingcrosslinkedpolyvinylalcoholcoatings AT davidmeridor controlledreleaseofhydrophilicactiveagentfromtextileusingcrosslinkedpolyvinylalcoholcoatings AT drorcohen controlledreleaseofhydrophilicactiveagentfromtextileusingcrosslinkedpolyvinylalcoholcoatings AT meitalportugalcohen controlledreleaseofhydrophilicactiveagentfromtextileusingcrosslinkedpolyvinylalcoholcoatings AT elizabethamir controlledreleaseofhydrophilicactiveagentfromtextileusingcrosslinkedpolyvinylalcoholcoatings |