Effects of vincristine on the properties of low threshold mechanoreceptors and high threshold mechanoreceptors in the hindpaw glabrous skin of mice

Abstract Vincristine is an important chemotherapy drug to treat various types of cancer, but it induces peripheral neuropathy, leading to numbness and mechanical allodynia in the hands and feet of patients. The peripheral neuropathy is a dose-limiting toxicity of vincristine chemotherapy. How vincri...

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Bibliographic Details
Main Authors: Akihiro Yamada, Ayaka I. Yamada, Jennifer Ling, Jianguo G. Gu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Brain
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Online Access:https://doi.org/10.1186/s13041-025-01223-9
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