Multi-omics data reveal that SAA1 + fibroblasts exacerbate periodontitis by regulating macrophage inflammation and chemotaxis

Multi-omics data reveal that SAA1 + fibroblasts exacerbate periodontitis by regulating macrophage inflammation and chemotaxis

Abstract Background Traditional techniques are limited in their ability to analyze the complex interaction mechanisms among multiple cell types within the periodontal microenvironment, thereby restricting the development of targeted therapies for periodontitis (PD). Utilizing multiomics technologies...

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Bibliographic Details
Main Authors: Li Li, Yuting Yang, Fang Dai, Libin Deng, Meixiu Jiang, Chenjiang He, Ting Long, Kaiqiang Yang, Xinbo Yang, Li Song
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Periodontitis
Single-cell RNA sequencing
Fibroblast
Macrophage infiltration
CellChat
SAA1
Online Access:https://doi.org/10.1186/s12967-025-06925-1
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https://doi.org/10.1186/s12967-025-06925-1

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