Reduced white matter integrity and disrupted brain network in children with type 2 and 3 spinal muscular atrophy

Reduced white matter integrity and disrupted brain network in children with type 2 and 3 spinal muscular atrophy

Abstract Background Spinal muscular atrophy (SMA) is caused by reduced expression of survival motor neuron (SMN) protein. Previous studies indicated SMA causes not only lower motor neuron degeneration but also extensive brain involvement. This study aimed to investigate the changes of brain white ma...

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Bibliographic Details
Main Authors: Huirong Nie, Shasha Lan, Huan Wang, Pei Xiang, Mengzhen Yan, Yang Fan, Wanqing Shen, Yijuan Li, Wen Tang, Zhiyun Yang, Yujian Liang, Yingqian Chen
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
Diffusion tensor imaging
Spinal muscular atrophy
Structural magnetic resonance imaging
White matter
Online Access:https://doi.org/10.1186/s11689-025-09592-x
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https://doi.org/10.1186/s11689-025-09592-x

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