Physical cues in biomaterials modulate macrophage polarization for bone regeneration: a review

Bone regeneration is a complex process governed by inflammation, angiogenesis, and tissue remodeling. Macrophages play central roles by dynamically shifting between pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes. While biochemical signals have been widely studied, emerging evidence high...

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Bibliographic Details
Main Authors: Tianxiao Yang, Zhurun Fang, Jin Zhang, Shengnai Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Bioengineering and Biotechnology
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Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1640560/full
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