Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo

Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo

Abstract Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines. Caspase‐1 also drives pyroptosis, a lytic cell d...

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Bibliographic Details
Main Authors: Damien Bertheloot, Carlos WS Wanderley, Ayda H Schneider, Lisa DJ Schiffelers, Jennifer D Wuerth, Jan MP Tödtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S Ribeiro, Lea‐Marie Jenster, Nathalia Rosero, Yonas M Tesfamariam, Fernando Q Cunha, Florian I Schmidt, Bernardo S Franklin
Format: Article
Language:English
Published: Springer Nature 2022-04-01
Series:EMBO Molecular Medicine
Subjects:
arthritis
extracellular inflammasomes
gout
nanobodies
pyroptosis
Online Access:https://doi.org/10.15252/emmm.202115415
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