Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke
Clinical and experimental data have demonstrated that inflammation plays fundamental roles in the pathogenesis of ischemic stroke. Interleukin-16 (IL-16) is identified as a proinflammatory cytokine that is a key element in the ischemic cascade after cerebral ischemia. We aimed to examine the relatio...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/564750 |
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| author | Xiao-li Liu Jian-zong Du Yu-miao Zhou Qin-fen Shu Ya-guo Li |
| author_facet | Xiao-li Liu Jian-zong Du Yu-miao Zhou Qin-fen Shu Ya-guo Li |
| author_sort | Xiao-li Liu |
| collection | DOAJ |
| description | Clinical and experimental data have demonstrated that inflammation plays fundamental roles in the pathogenesis of ischemic stroke. Interleukin-16 (IL-16) is identified as a proinflammatory cytokine that is a key element in the ischemic cascade after cerebral ischemia. We aimed to examine the relationship between the IL-16 polymorphisms and the risk of ischemic stroke in a Chinese population. A total of 198 patients with ischemic stroke and 236 controls were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing method. We found that the rs11556218TG genotype and G allele of IL-16 were associated with significantly increased risks of ischemic stroke (TG versus TT, adjusted OR = 1.88; 95% CI, 1.15–3.07; G versus T, adjusted OR = 1.54; 95% CI, 1.05–2.27, resp.). However, there were no significant differences in the genotype and allele frequencies of IL-16 rs4778889 T/C and rs4072111 C/T polymorphisms between the two groups, even after stratification analyses by age, gender, and the presence or absence of hypertension, diabetes mellitus, hypercholesterolemia, and hypertriglyceridemia. These findings indicate that the IL-16 polymorphism may be related to the etiology of ischemic stroke in the Chinese population. |
| format | Article |
| id | doaj-art-c7f393381acd427e9b84e6add05b7f11 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c7f393381acd427e9b84e6add05b7f112025-02-03T01:23:16ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/564750564750Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic StrokeXiao-li Liu0Jian-zong Du1Yu-miao Zhou2Qin-fen Shu3Ya-guo Li4Department of Neurology, Zhejiang Hospital, Hangzhou, Zhejiang 310013, ChinaDepartment of Respiratory, Zhejiang Hospital, Hangzhou, Zhejiang 310013, ChinaDepartment of Neurology, Zhejiang Hospital, Hangzhou, Zhejiang 310013, ChinaDepartment of Neurology, Zhejiang Hospital, Hangzhou, Zhejiang 310013, ChinaDepartment of Neurology, Zhejiang Hospital, Hangzhou, Zhejiang 310013, ChinaClinical and experimental data have demonstrated that inflammation plays fundamental roles in the pathogenesis of ischemic stroke. Interleukin-16 (IL-16) is identified as a proinflammatory cytokine that is a key element in the ischemic cascade after cerebral ischemia. We aimed to examine the relationship between the IL-16 polymorphisms and the risk of ischemic stroke in a Chinese population. A total of 198 patients with ischemic stroke and 236 controls were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing method. We found that the rs11556218TG genotype and G allele of IL-16 were associated with significantly increased risks of ischemic stroke (TG versus TT, adjusted OR = 1.88; 95% CI, 1.15–3.07; G versus T, adjusted OR = 1.54; 95% CI, 1.05–2.27, resp.). However, there were no significant differences in the genotype and allele frequencies of IL-16 rs4778889 T/C and rs4072111 C/T polymorphisms between the two groups, even after stratification analyses by age, gender, and the presence or absence of hypertension, diabetes mellitus, hypercholesterolemia, and hypertriglyceridemia. These findings indicate that the IL-16 polymorphism may be related to the etiology of ischemic stroke in the Chinese population.http://dx.doi.org/10.1155/2013/564750 |
| spellingShingle | Xiao-li Liu Jian-zong Du Yu-miao Zhou Qin-fen Shu Ya-guo Li Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke Mediators of Inflammation |
| title | Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke |
| title_full | Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke |
| title_fullStr | Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke |
| title_full_unstemmed | Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke |
| title_short | Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke |
| title_sort | interleukin 16 polymorphism is associated with an increased risk of ischemic stroke |
| url | http://dx.doi.org/10.1155/2013/564750 |
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