Endothelial Progenitors as Tools to Study Vascular Disease
Endothelial progenitor cells (EPCs) have great clinical value because they can be used as diagnostic biomarkers and as a cellular therapy for promoting vascular repair of ischaemic tissues. However, EPCs also have an additional research value in vascular disease modelling to interrogate human diseas...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/346735 |
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| _version_ | 1832548701155885056 |
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| author | Reinhold J. Medina Christina L. O'Neill T. Michelle O'Doherty Sarah E. J. Wilson Alan W. Stitt |
| author_facet | Reinhold J. Medina Christina L. O'Neill T. Michelle O'Doherty Sarah E. J. Wilson Alan W. Stitt |
| author_sort | Reinhold J. Medina |
| collection | DOAJ |
| description | Endothelial progenitor cells (EPCs) have great clinical value because they can be used as diagnostic biomarkers and as a cellular therapy for promoting vascular repair of ischaemic tissues. However, EPCs also have an additional research value in vascular disease modelling to interrogate human disease mechanisms. The term EPC is used to describe a diverse variety of cells, and we have identified a specific EPC subtype called outgrowth endothelial cell (OEC) as the best candidate for vascular disease modelling because of its high-proliferative potential and unambiguous endothelial commitment. OECs are isolated from human blood and can be exposed to pathologic conditions (forward approach) or be isolated from patients (reverse approach) in order to study vascular human disease. The use of OECs for modelling vascular disease will contribute greatly to improving our understanding of endothelial pathogenesis, which will potentially lead to the discovery of novel therapeutic strategies for vascular diseases. |
| format | Article |
| id | doaj-art-c7e9290e9b0e4e5690263b0f404afc7c |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-c7e9290e9b0e4e5690263b0f404afc7c2025-02-03T06:13:17ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/346735346735Endothelial Progenitors as Tools to Study Vascular DiseaseReinhold J. Medina0Christina L. O'Neill1T. Michelle O'Doherty2Sarah E. J. Wilson3Alan W. Stitt4Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Royal Victoria Hospital, Belfast BT12 6BA, UKCentre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Royal Victoria Hospital, Belfast BT12 6BA, UKCentre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Royal Victoria Hospital, Belfast BT12 6BA, UKCentre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Royal Victoria Hospital, Belfast BT12 6BA, UKCentre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Royal Victoria Hospital, Belfast BT12 6BA, UKEndothelial progenitor cells (EPCs) have great clinical value because they can be used as diagnostic biomarkers and as a cellular therapy for promoting vascular repair of ischaemic tissues. However, EPCs also have an additional research value in vascular disease modelling to interrogate human disease mechanisms. The term EPC is used to describe a diverse variety of cells, and we have identified a specific EPC subtype called outgrowth endothelial cell (OEC) as the best candidate for vascular disease modelling because of its high-proliferative potential and unambiguous endothelial commitment. OECs are isolated from human blood and can be exposed to pathologic conditions (forward approach) or be isolated from patients (reverse approach) in order to study vascular human disease. The use of OECs for modelling vascular disease will contribute greatly to improving our understanding of endothelial pathogenesis, which will potentially lead to the discovery of novel therapeutic strategies for vascular diseases.http://dx.doi.org/10.1155/2012/346735 |
| spellingShingle | Reinhold J. Medina Christina L. O'Neill T. Michelle O'Doherty Sarah E. J. Wilson Alan W. Stitt Endothelial Progenitors as Tools to Study Vascular Disease Stem Cells International |
| title | Endothelial Progenitors as Tools to Study Vascular Disease |
| title_full | Endothelial Progenitors as Tools to Study Vascular Disease |
| title_fullStr | Endothelial Progenitors as Tools to Study Vascular Disease |
| title_full_unstemmed | Endothelial Progenitors as Tools to Study Vascular Disease |
| title_short | Endothelial Progenitors as Tools to Study Vascular Disease |
| title_sort | endothelial progenitors as tools to study vascular disease |
| url | http://dx.doi.org/10.1155/2012/346735 |
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