Leontiasis ossea in the setting of chronic kidney disease and limited dialysis access: A case report with discussion of therapeutic implications
Leontiasis ossea, also known as craniofacial fibrous dysplasia, is a rare form of osseous hypertrophy of the facial bones associated with chronic kidney disease and secondary hyperparathyroidism. As the condition progresses, changes in bone structure can lead to severe facial disfigurement, respirat...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
|
| Series: | Radiology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043324013177 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832595798672539648 |
|---|---|
| author | Sebastian Maletz, BS Zackery Beauchamp, MD John Petrilli, MD, FAAFP |
| author_facet | Sebastian Maletz, BS Zackery Beauchamp, MD John Petrilli, MD, FAAFP |
| author_sort | Sebastian Maletz, BS |
| collection | DOAJ |
| description | Leontiasis ossea, also known as craniofacial fibrous dysplasia, is a rare form of osseous hypertrophy of the facial bones associated with chronic kidney disease and secondary hyperparathyroidism. As the condition progresses, changes in bone structure can lead to severe facial disfigurement, respiratory difficulties, dysarthria, and dysphagia. We describe the case of an approximately 30-year-old male with a long-standing history of end-stage renal disease who experienced rapidly progressing facial swelling and underlying bone changes following a period of poor access to dialysis. Despite brief symptomatic improvement following parathyroidectomy, the patient's hyperparathyroidism ultimately persisted. Subsequent immunomodulator therapy again offered subjective improvements but was discontinued in the setting of adverse effects. We provide a brief overview of the pathophysiology of leontiasis ossea, review imaging findings pertinent to the case presentation, and discuss relevant implications in the diagnosis and management of this disease. |
| format | Article |
| id | doaj-art-c7dd240afd8d4048ab86d5093e1d79eb |
| institution | Kabale University |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-c7dd240afd8d4048ab86d5093e1d79eb2025-01-18T05:03:54ZengElsevierRadiology Case Reports1930-04332025-03-0120313331337Leontiasis ossea in the setting of chronic kidney disease and limited dialysis access: A case report with discussion of therapeutic implicationsSebastian Maletz, BS0Zackery Beauchamp, MD1John Petrilli, MD, FAAFP2University of South Florida, Morsani College of Medicine, Tampa, FL, USA; Corresponding author.Department of Radiology, University of South Florida, Morsani College of Medicine, Tampa, FL, USADepartment of Family Medicine, University of South Florida, Morsani College of Medicine, Tampa, FL, USALeontiasis ossea, also known as craniofacial fibrous dysplasia, is a rare form of osseous hypertrophy of the facial bones associated with chronic kidney disease and secondary hyperparathyroidism. As the condition progresses, changes in bone structure can lead to severe facial disfigurement, respiratory difficulties, dysarthria, and dysphagia. We describe the case of an approximately 30-year-old male with a long-standing history of end-stage renal disease who experienced rapidly progressing facial swelling and underlying bone changes following a period of poor access to dialysis. Despite brief symptomatic improvement following parathyroidectomy, the patient's hyperparathyroidism ultimately persisted. Subsequent immunomodulator therapy again offered subjective improvements but was discontinued in the setting of adverse effects. We provide a brief overview of the pathophysiology of leontiasis ossea, review imaging findings pertinent to the case presentation, and discuss relevant implications in the diagnosis and management of this disease.http://www.sciencedirect.com/science/article/pii/S1930043324013177Uremic leontiasis osseaRenal osteodystrophyHyperparathyroidismCraniofacial fibrous dysplasia |
| spellingShingle | Sebastian Maletz, BS Zackery Beauchamp, MD John Petrilli, MD, FAAFP Leontiasis ossea in the setting of chronic kidney disease and limited dialysis access: A case report with discussion of therapeutic implications Radiology Case Reports Uremic leontiasis ossea Renal osteodystrophy Hyperparathyroidism Craniofacial fibrous dysplasia |
| title | Leontiasis ossea in the setting of chronic kidney disease and limited dialysis access: A case report with discussion of therapeutic implications |
| title_full | Leontiasis ossea in the setting of chronic kidney disease and limited dialysis access: A case report with discussion of therapeutic implications |
| title_fullStr | Leontiasis ossea in the setting of chronic kidney disease and limited dialysis access: A case report with discussion of therapeutic implications |
| title_full_unstemmed | Leontiasis ossea in the setting of chronic kidney disease and limited dialysis access: A case report with discussion of therapeutic implications |
| title_short | Leontiasis ossea in the setting of chronic kidney disease and limited dialysis access: A case report with discussion of therapeutic implications |
| title_sort | leontiasis ossea in the setting of chronic kidney disease and limited dialysis access a case report with discussion of therapeutic implications |
| topic | Uremic leontiasis ossea Renal osteodystrophy Hyperparathyroidism Craniofacial fibrous dysplasia |
| url | http://www.sciencedirect.com/science/article/pii/S1930043324013177 |
| work_keys_str_mv | AT sebastianmaletzbs leontiasisosseainthesettingofchronickidneydiseaseandlimiteddialysisaccessacasereportwithdiscussionoftherapeuticimplications AT zackerybeauchampmd leontiasisosseainthesettingofchronickidneydiseaseandlimiteddialysisaccessacasereportwithdiscussionoftherapeuticimplications AT johnpetrillimdfaafp leontiasisosseainthesettingofchronickidneydiseaseandlimiteddialysisaccessacasereportwithdiscussionoftherapeuticimplications |