In Vivo Molecular Imaging in Retinal Disease
There is an urgent need for early diagnosis in medicine, whereupon effective treatments could prevent irreversible tissue damage. The special structure of the eye provides a unique opportunity for noninvasive light-based imaging of ocular fundus vasculature. To detect endothelial injury at the early...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2012/429387 |
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| _version_ | 1832564145719869440 |
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| author | Fang Xie Wenting Luo Zhongyu Zhang Dawei Sun |
| author_facet | Fang Xie Wenting Luo Zhongyu Zhang Dawei Sun |
| author_sort | Fang Xie |
| collection | DOAJ |
| description | There is an urgent need for early diagnosis in medicine, whereupon effective treatments could prevent irreversible tissue damage. The special structure of the eye provides a unique opportunity for noninvasive light-based imaging of ocular fundus vasculature. To detect endothelial injury at the early and reversible stage of adhesion molecule upregulation, some novel imaging agents that target retinal endothelial molecules were generated. In vivo molecular imaging has a great potential to impact medicine by detecting diseases or screening disease in early stages, identifying extent of disease, selecting disease and patient-specific therapeutic treatment, applying a directed or targeted therapy, and measuring molecular-specific effects of treatment. Current preclinical findings and advances in instrumentation such as endoscopes and microcatheters suggest that these molecular imaging modalities have numerous clinical applications and will be translated into clinical use in the near future. |
| format | Article |
| id | doaj-art-c7d8d29722ce4877a60ae00d3567c4e9 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-c7d8d29722ce4877a60ae00d3567c4e92025-02-03T01:11:44ZengWileyJournal of Ophthalmology2090-004X2090-00582012-01-01201210.1155/2012/429387429387In Vivo Molecular Imaging in Retinal DiseaseFang Xie0Wenting Luo1Zhongyu Zhang2Dawei Sun3Department of Ophthalmology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, ChinaDepartment of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Harbin 150081, ChinaDepartment of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Harbin 150081, ChinaDepartment of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Harbin 150081, ChinaThere is an urgent need for early diagnosis in medicine, whereupon effective treatments could prevent irreversible tissue damage. The special structure of the eye provides a unique opportunity for noninvasive light-based imaging of ocular fundus vasculature. To detect endothelial injury at the early and reversible stage of adhesion molecule upregulation, some novel imaging agents that target retinal endothelial molecules were generated. In vivo molecular imaging has a great potential to impact medicine by detecting diseases or screening disease in early stages, identifying extent of disease, selecting disease and patient-specific therapeutic treatment, applying a directed or targeted therapy, and measuring molecular-specific effects of treatment. Current preclinical findings and advances in instrumentation such as endoscopes and microcatheters suggest that these molecular imaging modalities have numerous clinical applications and will be translated into clinical use in the near future.http://dx.doi.org/10.1155/2012/429387 |
| spellingShingle | Fang Xie Wenting Luo Zhongyu Zhang Dawei Sun In Vivo Molecular Imaging in Retinal Disease Journal of Ophthalmology |
| title | In Vivo Molecular Imaging in Retinal Disease |
| title_full | In Vivo Molecular Imaging in Retinal Disease |
| title_fullStr | In Vivo Molecular Imaging in Retinal Disease |
| title_full_unstemmed | In Vivo Molecular Imaging in Retinal Disease |
| title_short | In Vivo Molecular Imaging in Retinal Disease |
| title_sort | in vivo molecular imaging in retinal disease |
| url | http://dx.doi.org/10.1155/2012/429387 |
| work_keys_str_mv | AT fangxie invivomolecularimaginginretinaldisease AT wentingluo invivomolecularimaginginretinaldisease AT zhongyuzhang invivomolecularimaginginretinaldisease AT daweisun invivomolecularimaginginretinaldisease |