Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model

Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model

We tested the hypothesis that Lipofectamine siRNA delivery to deplete transient receptor potential cation channel (TRPC) 1 protein expression can suppress hypoxia-induced pulmonary arterial hypertension (PAH) in mice. Adult male C57BL/6 mice were equally divided into group 1 (normal controls), grou...

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Main Authors: Cheuk-Kwan Sun, Yen-Yi Zhen, Hung-I Lu, Pei-Hsun Sung, Li-Teh Chang, Tzu-Hsien Tsai, Jiunn-Jye Sheu, Yung-Lung Chen, Sarah Chua, Hsueh-Wen Chang, Yi-Ling Chen, Fan-Yen Lee, Hon-Kan Yip
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2014/316214
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http://dx.doi.org/10.1155/2014/316214

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