Enhancing tumor immunotherapy with smart nanoparticles for reprogramming macrophages and blocking the CD47/Sirpα pathway

Enhancing tumor immunotherapy with smart nanoparticles for reprogramming macrophages and blocking the CD47/Sirpα pathway

Immunotherapy has significantly advanced cancer treatment, but the tumor immune microenvironment (TIME) often remains immunosuppressive, limiting therapeutic efficacy. Tumor-associated macrophages (TAMs), particularly M2-like macrophages, play a crucial role in promoting tumor growth and immune evas...

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Bibliographic Details
Main Authors: Zubair Hussain, Shanshan Gou, Xu Liu, Mengyu Li, Hanyue Zhang, Sumei Ren, Ruxia Han, Fangfang Liu, Xiaowen Zhou, Lu Qiu, Hongfei Wang, Zhenzhen Chen, Kangdong Liu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Materials Today Bio
Subjects:
Tumor immunotherapy
Tumor-associated macrophage
STING agonist
CD47/Sirpα axis
Smart PMM-Expressing cell membrane
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425003862
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http://www.sciencedirect.com/science/article/pii/S2590006425003862

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