Genetic Rat Models of Parkinson's Disease
Parkinson’s disease (PD) is a neurodegenerative disease characterized by a specific loss of dopaminergic neurons. Although the vast majority of PD cases are idiopathic in nature, there is a subset that contains genetic links. Of the genes that have been linked to PD, α-synuclein and leucine-rich r...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2012/128356 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558617861029888 |
|---|---|
| author | Ryan M. Welchko Xavier T. Lévêque Gary L. Dunbar |
| author_facet | Ryan M. Welchko Xavier T. Lévêque Gary L. Dunbar |
| author_sort | Ryan M. Welchko |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a neurodegenerative disease characterized by a specific loss of dopaminergic neurons. Although the vast majority of PD cases are idiopathic in nature, there is a subset that contains genetic links. Of the genes that have been linked to PD, α-synuclein and leucine-rich repeat kinase 2 have been used to develop transgenic rat models of the disease. In this paper we focused on the various transgenic rat models of PD in terms of their ability to mimic key symptoms of PD in a progressive manner. In general, we found that most of these models provided useful tools for the early stages of PD, but the development of new transgenic rats that present significant neuropathologic and motoric deficits in a progressive manner that more accurately mimics PD is needed. |
| format | Article |
| id | doaj-art-c7704506a195450e80c011f73f98104b |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-c7704506a195450e80c011f73f98104b2025-02-03T01:32:03ZengWileyParkinson's Disease2090-80832042-00802012-01-01201210.1155/2012/128356128356Genetic Rat Models of Parkinson's DiseaseRyan M. Welchko0Xavier T. Lévêque1Gary L. Dunbar2Field Neurosciences Institute, Laboratory for Restorative Neurology, Department of Psychology, Central Michigan University, Mt. Pleasant, MI 48859, USAField Neurosciences Institute, Laboratory for Restorative Neurology, Program in Neuroscience, Central Michigan University, Mt. Pleasant, MI 48859, USAField Neurosciences Institute, Laboratory for Restorative Neurology, Department of Psychology and Program in Neuroscience, College of Medicine, Central Michigan University, Mt. Pleasant, MI 48859, USAParkinson’s disease (PD) is a neurodegenerative disease characterized by a specific loss of dopaminergic neurons. Although the vast majority of PD cases are idiopathic in nature, there is a subset that contains genetic links. Of the genes that have been linked to PD, α-synuclein and leucine-rich repeat kinase 2 have been used to develop transgenic rat models of the disease. In this paper we focused on the various transgenic rat models of PD in terms of their ability to mimic key symptoms of PD in a progressive manner. In general, we found that most of these models provided useful tools for the early stages of PD, but the development of new transgenic rats that present significant neuropathologic and motoric deficits in a progressive manner that more accurately mimics PD is needed.http://dx.doi.org/10.1155/2012/128356 |
| spellingShingle | Ryan M. Welchko Xavier T. Lévêque Gary L. Dunbar Genetic Rat Models of Parkinson's Disease Parkinson's Disease |
| title | Genetic Rat Models of Parkinson's Disease |
| title_full | Genetic Rat Models of Parkinson's Disease |
| title_fullStr | Genetic Rat Models of Parkinson's Disease |
| title_full_unstemmed | Genetic Rat Models of Parkinson's Disease |
| title_short | Genetic Rat Models of Parkinson's Disease |
| title_sort | genetic rat models of parkinson s disease |
| url | http://dx.doi.org/10.1155/2012/128356 |
| work_keys_str_mv | AT ryanmwelchko geneticratmodelsofparkinsonsdisease AT xaviertleveque geneticratmodelsofparkinsonsdisease AT garyldunbar geneticratmodelsofparkinsonsdisease |