Safety of Ovarian Tissue Autotransplantation for Cancer Patients
Cancer treatments can induce premature ovarian failure in almost half of young women suffering from invasive neoplasia. Cryopreservation of ovarian cortex and subsequent autotransplantation of frozen-thawed tissue have emerged as promising alternatives to conventional fertility preservation technolo...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2012/495142 |
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| _version_ | 1832568105825468416 |
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| author | Laurence Bockstaele Sophie Tsepelidis Julie Dechene Yvon Englert Isabelle Demeestere |
| author_facet | Laurence Bockstaele Sophie Tsepelidis Julie Dechene Yvon Englert Isabelle Demeestere |
| author_sort | Laurence Bockstaele |
| collection | DOAJ |
| description | Cancer treatments can induce premature ovarian failure in almost half of young women suffering from invasive neoplasia. Cryopreservation of ovarian cortex and subsequent autotransplantation of frozen-thawed tissue have emerged as promising alternatives to conventional fertility preservation technologies. However, human ovarian tissue is generally harvested before the administration of gonadotoxic treatment and could be contaminated with malignant cells. The safety of autotransplantation of ovarian cortex remains a major concern for fertility preservation units worldwide. This paper discusses the main tools for detecting disseminated cancer cells currently available, their limitations, and clinical relevance. |
| format | Article |
| id | doaj-art-c75fdd01939e44aba83836ae8fdd4f73 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-c75fdd01939e44aba83836ae8fdd4f732025-02-03T00:59:49ZengWileyObstetrics and Gynecology International1687-95891687-95972012-01-01201210.1155/2012/495142495142Safety of Ovarian Tissue Autotransplantation for Cancer PatientsLaurence Bockstaele0Sophie Tsepelidis1Julie Dechene2Yvon Englert3Isabelle Demeestere4Research Laboratory on Human Reproduction, Faculty of Medicine, Free University of Brussels, 808, Route de Lennik, 1070 Bruxelles, BelgiumResearch Laboratory on Human Reproduction, Faculty of Medicine, Free University of Brussels, 808, Route de Lennik, 1070 Bruxelles, BelgiumResearch Laboratory on Human Reproduction, Faculty of Medicine, Free University of Brussels, 808, Route de Lennik, 1070 Bruxelles, BelgiumResearch Laboratory on Human Reproduction, Faculty of Medicine, Free University of Brussels, 808, Route de Lennik, 1070 Bruxelles, BelgiumResearch Laboratory on Human Reproduction, Faculty of Medicine, Free University of Brussels, 808, Route de Lennik, 1070 Bruxelles, BelgiumCancer treatments can induce premature ovarian failure in almost half of young women suffering from invasive neoplasia. Cryopreservation of ovarian cortex and subsequent autotransplantation of frozen-thawed tissue have emerged as promising alternatives to conventional fertility preservation technologies. However, human ovarian tissue is generally harvested before the administration of gonadotoxic treatment and could be contaminated with malignant cells. The safety of autotransplantation of ovarian cortex remains a major concern for fertility preservation units worldwide. This paper discusses the main tools for detecting disseminated cancer cells currently available, their limitations, and clinical relevance.http://dx.doi.org/10.1155/2012/495142 |
| spellingShingle | Laurence Bockstaele Sophie Tsepelidis Julie Dechene Yvon Englert Isabelle Demeestere Safety of Ovarian Tissue Autotransplantation for Cancer Patients Obstetrics and Gynecology International |
| title | Safety of Ovarian Tissue Autotransplantation for Cancer Patients |
| title_full | Safety of Ovarian Tissue Autotransplantation for Cancer Patients |
| title_fullStr | Safety of Ovarian Tissue Autotransplantation for Cancer Patients |
| title_full_unstemmed | Safety of Ovarian Tissue Autotransplantation for Cancer Patients |
| title_short | Safety of Ovarian Tissue Autotransplantation for Cancer Patients |
| title_sort | safety of ovarian tissue autotransplantation for cancer patients |
| url | http://dx.doi.org/10.1155/2012/495142 |
| work_keys_str_mv | AT laurencebockstaele safetyofovariantissueautotransplantationforcancerpatients AT sophietsepelidis safetyofovariantissueautotransplantationforcancerpatients AT juliedechene safetyofovariantissueautotransplantationforcancerpatients AT yvonenglert safetyofovariantissueautotransplantationforcancerpatients AT isabelledemeestere safetyofovariantissueautotransplantationforcancerpatients |