Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study.

Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study.

<h4>Background</h4>Paraoxonase-1 (PON1) is an antioxidant enzyme, that resides on high-density lipoprotein (HDL). PON1-activity, is heavily influenced by the PON1-Q192R polymorphism. PON1 is considered to protect against atherosclerosis, but it is unclear whether this relation is indepen...

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Main Authors: Rakesh S Birjmohun, Menno Vergeer, Erik S G Stroes, Manjinder S Sandhu, Sally L Ricketts, Michael W Tanck, Nicholas J Wareham, J Wouter Jukema, John J P Kastelein, Kay-Tee Khaw, S Matthijs Boekholdt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0006809&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0006809&type=printable

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