Persistence of Diarrheal Pathogens Is Associated with Continued Recruitment of Plasmablasts in the Circulation
Intestinal antigen encounter leads to recirculation of antigen-specific plasmablasts via lymphatics and blood back to the intestine. Investigating these gut-originating cells in blood provides a less invasive tool for studying intestinal immune responses, with the limitation that the cells disappear...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/279206 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568245618475008 |
|---|---|
| author | Anu Kantele |
| author_facet | Anu Kantele |
| author_sort | Anu Kantele |
| collection | DOAJ |
| description | Intestinal antigen encounter leads to recirculation of antigen-specific plasmablasts via lymphatics and blood back to the intestine. Investigating these gut-originating cells in blood provides a less invasive tool for studying intestinal immune responses, with the limitation that the cells disappear from the circulation in two weeks. No data exist on situations where pathogens persist in the intestine.
Patients with Salmonella, Yersinia, or Campylobacter gastroenteritis and volunteers receiving an oral typhoid vaccine were assayed for plasmablasts specific to each subject's own pathogen/antigen weekly until the response faded. In vaccinees, plasmablasts disappeared in two weeks. In gastroenteritis, the response faded 2-3 and 3–7 weeks after the last positive Salmonella or Yersinia stool culture.
Even in symptomless patients, pathogens persisting in the intestine keep seeding plasmablasts into the circulation. Assaying these cells might offer a powerful tool for research into diseases in which persisting microbes have a potential pathogenetic significance. |
| format | Article |
| id | doaj-art-c740fa8d7a78405a86de58b762b1b095 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-c740fa8d7a78405a86de58b762b1b0952025-02-03T00:59:26ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/279206279206Persistence of Diarrheal Pathogens Is Associated with Continued Recruitment of Plasmablasts in the CirculationAnu Kantele0Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, Aurora Hospital, Building 5, 3rd floor, POB 348, 00029 Helsinki, FinlandIntestinal antigen encounter leads to recirculation of antigen-specific plasmablasts via lymphatics and blood back to the intestine. Investigating these gut-originating cells in blood provides a less invasive tool for studying intestinal immune responses, with the limitation that the cells disappear from the circulation in two weeks. No data exist on situations where pathogens persist in the intestine. Patients with Salmonella, Yersinia, or Campylobacter gastroenteritis and volunteers receiving an oral typhoid vaccine were assayed for plasmablasts specific to each subject's own pathogen/antigen weekly until the response faded. In vaccinees, plasmablasts disappeared in two weeks. In gastroenteritis, the response faded 2-3 and 3–7 weeks after the last positive Salmonella or Yersinia stool culture. Even in symptomless patients, pathogens persisting in the intestine keep seeding plasmablasts into the circulation. Assaying these cells might offer a powerful tool for research into diseases in which persisting microbes have a potential pathogenetic significance.http://dx.doi.org/10.1155/2012/279206 |
| spellingShingle | Anu Kantele Persistence of Diarrheal Pathogens Is Associated with Continued Recruitment of Plasmablasts in the Circulation Clinical and Developmental Immunology |
| title | Persistence of Diarrheal Pathogens Is Associated with Continued Recruitment of Plasmablasts in the Circulation |
| title_full | Persistence of Diarrheal Pathogens Is Associated with Continued Recruitment of Plasmablasts in the Circulation |
| title_fullStr | Persistence of Diarrheal Pathogens Is Associated with Continued Recruitment of Plasmablasts in the Circulation |
| title_full_unstemmed | Persistence of Diarrheal Pathogens Is Associated with Continued Recruitment of Plasmablasts in the Circulation |
| title_short | Persistence of Diarrheal Pathogens Is Associated with Continued Recruitment of Plasmablasts in the Circulation |
| title_sort | persistence of diarrheal pathogens is associated with continued recruitment of plasmablasts in the circulation |
| url | http://dx.doi.org/10.1155/2012/279206 |
| work_keys_str_mv | AT anukantele persistenceofdiarrhealpathogensisassociatedwithcontinuedrecruitmentofplasmablastsinthecirculation |