COVID-19 in discharged patients with diabetes and chronic kidney disease: one-year follow-up and evaluation
PurposeTo evaluate the all-cause mortality rate and renal outcomes in patients with diabetes and chronic kidney disease (CKD) following hospital discharge for COVID-19.MethodsThis single-center prospective observational study included 187 discharged COVID-19 patients with diabetes and CKD, admitted...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1519993/full |
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| author | Enrong Ran Enrong Ran Yutong Zou Chuanyi Zhao Kai Liu Jiamin Yuan Wenjie Yang Lijun Zhao Qing Yang Jia Yang Xuegui Ju Linli Cai Yanlin Lang Xingyuan Li Ke Liu Fang Liu Fang Liu |
| author_facet | Enrong Ran Enrong Ran Yutong Zou Chuanyi Zhao Kai Liu Jiamin Yuan Wenjie Yang Lijun Zhao Qing Yang Jia Yang Xuegui Ju Linli Cai Yanlin Lang Xingyuan Li Ke Liu Fang Liu Fang Liu |
| author_sort | Enrong Ran |
| collection | DOAJ |
| description | PurposeTo evaluate the all-cause mortality rate and renal outcomes in patients with diabetes and chronic kidney disease (CKD) following hospital discharge for COVID-19.MethodsThis single-center prospective observational study included 187 discharged COVID-19 patients with diabetes and CKD, admitted between December 2022 and January 2023 at West China Hospital, Sichuan University. Cox regression analysis was used to assess mortality risk, and logistic regression was applied to identify risk factors for rapid CKD progression after discharge.ResultsDuring the one-year follow-up, the all-cause mortality rate was 26.7%, with a COVID-19-related acute kidney injury (AKI) incidence of 35.3%, and 35.8% of patients experienced rapid CKD progression after discharge. Cox proportional hazards regression indicated that sepsis and mechanical ventilation were major risk factors for post-discharge all-cause mortality. Logistic regression identified baseline eGFR < 60 mL/min/1.73 m² as an independent risk factor for rapid CKD progression.ConclusionsDuring the one-year follow-up period, we observed that patients with diabetes and CKD exhibited higher all-cause mortality and experienced rapid deterioration of kidney function after acute infection with COVID-19. This underscores the importance of ongoing longitudinal follow-up to more accurately track the long-term health effects of COVID-19 on patients with diabetes and CKD. |
| format | Article |
| id | doaj-art-c72c598b4e58406d98f7ad7640eb9ce5 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-c72c598b4e58406d98f7ad7640eb9ce52025-02-04T05:28:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.15199931519993COVID-19 in discharged patients with diabetes and chronic kidney disease: one-year follow-up and evaluationEnrong Ran0Enrong Ran1Yutong Zou2Chuanyi Zhao3Kai Liu4Jiamin Yuan5Wenjie Yang6Lijun Zhao7Qing Yang8Jia Yang9Xuegui Ju10Linli Cai11Yanlin Lang12Xingyuan Li13Ke Liu14Fang Liu15Fang Liu16Department of Nephrology, West China Hospital, Sichuan University; Laboratory of Diabetic Kidney Disease, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Nephrology, Suining Central Hospital, Suining, ChinaDepartment of Nephrology, West China Hospital, Sichuan University; Laboratory of Diabetic Kidney Disease, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Clinical Research Management, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Nephrology, West China Hospital, Sichuan University; Laboratory of Diabetic Kidney Disease, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Nephrology, West China Hospital, Sichuan University; Laboratory of Diabetic Kidney Disease, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDivision of Project Design and Statistics, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Nephrology, West China Hospital, Sichuan University; Laboratory of Diabetic Kidney Disease, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Nephrology, West China Hospital, Sichuan University; Laboratory of Diabetic Kidney Disease, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Nephrology, West China Hospital, Sichuan University; Laboratory of Diabetic Kidney Disease, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Nephrology, West China Hospital, Sichuan University; Laboratory of Diabetic Kidney Disease, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Nephrology, West China Hospital, Sichuan University; Laboratory of Diabetic Kidney Disease, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Nephrology, West China Hospital, Sichuan University; Laboratory of Diabetic Kidney Disease, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Clinical Research Management, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Nephrology, West China Hospital, Sichuan University; Laboratory of Diabetic Kidney Disease, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Nephrology, West China Hospital, Sichuan University; Laboratory of Diabetic Kidney Disease, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Clinical Research Management, West China Hospital of Sichuan University, Chengdu, ChinaPurposeTo evaluate the all-cause mortality rate and renal outcomes in patients with diabetes and chronic kidney disease (CKD) following hospital discharge for COVID-19.MethodsThis single-center prospective observational study included 187 discharged COVID-19 patients with diabetes and CKD, admitted between December 2022 and January 2023 at West China Hospital, Sichuan University. Cox regression analysis was used to assess mortality risk, and logistic regression was applied to identify risk factors for rapid CKD progression after discharge.ResultsDuring the one-year follow-up, the all-cause mortality rate was 26.7%, with a COVID-19-related acute kidney injury (AKI) incidence of 35.3%, and 35.8% of patients experienced rapid CKD progression after discharge. Cox proportional hazards regression indicated that sepsis and mechanical ventilation were major risk factors for post-discharge all-cause mortality. Logistic regression identified baseline eGFR < 60 mL/min/1.73 m² as an independent risk factor for rapid CKD progression.ConclusionsDuring the one-year follow-up period, we observed that patients with diabetes and CKD exhibited higher all-cause mortality and experienced rapid deterioration of kidney function after acute infection with COVID-19. This underscores the importance of ongoing longitudinal follow-up to more accurately track the long-term health effects of COVID-19 on patients with diabetes and CKD.https://www.frontiersin.org/articles/10.3389/fendo.2025.1519993/fullCOVID-19diabeteschronic kidney diseaseacute kidney injurymortality |
| spellingShingle | Enrong Ran Enrong Ran Yutong Zou Chuanyi Zhao Kai Liu Jiamin Yuan Wenjie Yang Lijun Zhao Qing Yang Jia Yang Xuegui Ju Linli Cai Yanlin Lang Xingyuan Li Ke Liu Fang Liu Fang Liu COVID-19 in discharged patients with diabetes and chronic kidney disease: one-year follow-up and evaluation Frontiers in Endocrinology COVID-19 diabetes chronic kidney disease acute kidney injury mortality |
| title | COVID-19 in discharged patients with diabetes and chronic kidney disease: one-year follow-up and evaluation |
| title_full | COVID-19 in discharged patients with diabetes and chronic kidney disease: one-year follow-up and evaluation |
| title_fullStr | COVID-19 in discharged patients with diabetes and chronic kidney disease: one-year follow-up and evaluation |
| title_full_unstemmed | COVID-19 in discharged patients with diabetes and chronic kidney disease: one-year follow-up and evaluation |
| title_short | COVID-19 in discharged patients with diabetes and chronic kidney disease: one-year follow-up and evaluation |
| title_sort | covid 19 in discharged patients with diabetes and chronic kidney disease one year follow up and evaluation |
| topic | COVID-19 diabetes chronic kidney disease acute kidney injury mortality |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1519993/full |
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