Rat models of frozen shoulder: Classification and evaluation
Abstract Frozen shoulder (FS), also known as adhesive capsulitis, is a condition that causes contraction and stiffness of the shoulder joint capsule. The main symptoms are persistent shoulder pain and a limited range of motion in all directions. These symptoms and poor prognosis affect people's...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Animal Models and Experimental Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ame2.12516 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087830033072128 |
|---|---|
| author | Hezirui Gu Wenqing Xie Hengzhen Li Shuguang Liu Yusheng Li |
| author_facet | Hezirui Gu Wenqing Xie Hengzhen Li Shuguang Liu Yusheng Li |
| author_sort | Hezirui Gu |
| collection | DOAJ |
| description | Abstract Frozen shoulder (FS), also known as adhesive capsulitis, is a condition that causes contraction and stiffness of the shoulder joint capsule. The main symptoms are persistent shoulder pain and a limited range of motion in all directions. These symptoms and poor prognosis affect people's physical health and quality of life. Currently, the specific mechanisms of FS remain unclear, and there is variability in treatment methods and their efficacy. Additionally, the early symptoms of FS are difficult to distinguish from those of other shoulder diseases, complicating early diagnosis and treatment. Therefore, it is necessary to develop and utilize animal models to understand the pathogenesis of FS and to explore treatment strategies, providing insights into the prevention and treatment of human FS. This paper reviews the rat models available for FS research, including external immobilization models, surgical internal immobilization models, injection modeling models, and endocrine modeling models. It introduces the basic procedures for these models and compares and analyzes the advantages, disadvantages, and applicability of each modeling method. Finally, our paper summarizes the common methods for evaluating FS rat models. |
| format | Article |
| id | doaj-art-c716b0b0c84343abb33f62e9d282ed1e |
| institution | Kabale University |
| issn | 2576-2095 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj-art-c716b0b0c84343abb33f62e9d282ed1e2025-02-06T03:52:55ZengWileyAnimal Models and Experimental Medicine2576-20952025-01-01819210110.1002/ame2.12516Rat models of frozen shoulder: Classification and evaluationHezirui Gu0Wenqing Xie1Hengzhen Li2Shuguang Liu3Yusheng Li4Department of Orthopedics, Xiangya Hospital Central South University Changsha ChinaDepartment of Orthopedics, Xiangya Hospital Central South University Changsha ChinaDepartment of Orthopedics, Xiangya Hospital Central South University Changsha ChinaDepartment of Joint Surgery, Honghui Hospital Xi'an Jiaotong University Xi'an ChinaDepartment of Orthopedics, Xiangya Hospital Central South University Changsha ChinaAbstract Frozen shoulder (FS), also known as adhesive capsulitis, is a condition that causes contraction and stiffness of the shoulder joint capsule. The main symptoms are persistent shoulder pain and a limited range of motion in all directions. These symptoms and poor prognosis affect people's physical health and quality of life. Currently, the specific mechanisms of FS remain unclear, and there is variability in treatment methods and their efficacy. Additionally, the early symptoms of FS are difficult to distinguish from those of other shoulder diseases, complicating early diagnosis and treatment. Therefore, it is necessary to develop and utilize animal models to understand the pathogenesis of FS and to explore treatment strategies, providing insights into the prevention and treatment of human FS. This paper reviews the rat models available for FS research, including external immobilization models, surgical internal immobilization models, injection modeling models, and endocrine modeling models. It introduces the basic procedures for these models and compares and analyzes the advantages, disadvantages, and applicability of each modeling method. Finally, our paper summarizes the common methods for evaluating FS rat models.https://doi.org/10.1002/ame2.12516endocrine modelinginjectionrat modelsurgical internal immobilization |
| spellingShingle | Hezirui Gu Wenqing Xie Hengzhen Li Shuguang Liu Yusheng Li Rat models of frozen shoulder: Classification and evaluation Animal Models and Experimental Medicine endocrine modeling injection rat model surgical internal immobilization |
| title | Rat models of frozen shoulder: Classification and evaluation |
| title_full | Rat models of frozen shoulder: Classification and evaluation |
| title_fullStr | Rat models of frozen shoulder: Classification and evaluation |
| title_full_unstemmed | Rat models of frozen shoulder: Classification and evaluation |
| title_short | Rat models of frozen shoulder: Classification and evaluation |
| title_sort | rat models of frozen shoulder classification and evaluation |
| topic | endocrine modeling injection rat model surgical internal immobilization |
| url | https://doi.org/10.1002/ame2.12516 |
| work_keys_str_mv | AT heziruigu ratmodelsoffrozenshoulderclassificationandevaluation AT wenqingxie ratmodelsoffrozenshoulderclassificationandevaluation AT hengzhenli ratmodelsoffrozenshoulderclassificationandevaluation AT shuguangliu ratmodelsoffrozenshoulderclassificationandevaluation AT yushengli ratmodelsoffrozenshoulderclassificationandevaluation |