Phytochemicals Mediated Remediation of Neurotoxicity Induced by Heavy Metals
Almost all the environmental components including both the abiotic and biotic factors have been consistently threatened by excessive contamination of heavy metals continuously released from various sources. Different heavy metals have been reported to generate adverse effects in many ways. Heavy met...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2015/534769 |
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| author | Vivek Kumar Gupta Shweta Singh Anju Agrawal Nikhat Jamal Siddiqi Bechan Sharma |
| author_facet | Vivek Kumar Gupta Shweta Singh Anju Agrawal Nikhat Jamal Siddiqi Bechan Sharma |
| author_sort | Vivek Kumar Gupta |
| collection | DOAJ |
| description | Almost all the environmental components including both the abiotic and biotic factors have been consistently threatened by excessive contamination of heavy metals continuously released from various sources. Different heavy metals have been reported to generate adverse effects in many ways. Heavy metals induced neurotoxicity and impairment in signalling cascade leading to cell death (apoptosis) has been indicated by several workers. On one hand, these metals are required by the cellular systems to regulate various biological functions of normal cells, while on the other their biomagnification in the cellular systems produces adverse effects. The mechanism by which the heavy metals induce neurotoxicity follows free radicals production pathway(s) specially the generation of reactive oxygen species and reactive nitrogen species. These free radicals produced in excess have been shown to create an imbalance between the oxidative and antioxidative systems leading to emergence of oxidative stress, which may cause necrosis, DNA damage, and many neurodegenerative disorders. This mini review summarizes the current knowledge available on the protective role of varied natural products isolated from different herbs/plants in imparting protection against heavy metals (cadmium, lead, arsenic, and mercury) mediated neurotoxicity. |
| format | Article |
| id | doaj-art-c70b246524de4226944c1834c77f6370 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-c70b246524de4226944c1834c77f63702025-02-03T01:20:57ZengWileyBiochemistry Research International2090-22472090-22552015-01-01201510.1155/2015/534769534769Phytochemicals Mediated Remediation of Neurotoxicity Induced by Heavy MetalsVivek Kumar Gupta0Shweta Singh1Anju Agrawal2Nikhat Jamal Siddiqi3Bechan Sharma4Department of Biochemistry, University of Allahabad, Allahabad 211002, IndiaDepartment of Biochemistry, University of Allahabad, Allahabad 211002, IndiaDepartment of Zoology, SNBVPG College, CSJM University, Kanpur 208001, IndiaDepartment of Biochemistry, College of Science, P.O. Box 22452, King Saud University, Riyadh 11495, Saudi ArabiaDepartment of Biochemistry, University of Allahabad, Allahabad 211002, IndiaAlmost all the environmental components including both the abiotic and biotic factors have been consistently threatened by excessive contamination of heavy metals continuously released from various sources. Different heavy metals have been reported to generate adverse effects in many ways. Heavy metals induced neurotoxicity and impairment in signalling cascade leading to cell death (apoptosis) has been indicated by several workers. On one hand, these metals are required by the cellular systems to regulate various biological functions of normal cells, while on the other their biomagnification in the cellular systems produces adverse effects. The mechanism by which the heavy metals induce neurotoxicity follows free radicals production pathway(s) specially the generation of reactive oxygen species and reactive nitrogen species. These free radicals produced in excess have been shown to create an imbalance between the oxidative and antioxidative systems leading to emergence of oxidative stress, which may cause necrosis, DNA damage, and many neurodegenerative disorders. This mini review summarizes the current knowledge available on the protective role of varied natural products isolated from different herbs/plants in imparting protection against heavy metals (cadmium, lead, arsenic, and mercury) mediated neurotoxicity.http://dx.doi.org/10.1155/2015/534769 |
| spellingShingle | Vivek Kumar Gupta Shweta Singh Anju Agrawal Nikhat Jamal Siddiqi Bechan Sharma Phytochemicals Mediated Remediation of Neurotoxicity Induced by Heavy Metals Biochemistry Research International |
| title | Phytochemicals Mediated Remediation of Neurotoxicity Induced by Heavy Metals |
| title_full | Phytochemicals Mediated Remediation of Neurotoxicity Induced by Heavy Metals |
| title_fullStr | Phytochemicals Mediated Remediation of Neurotoxicity Induced by Heavy Metals |
| title_full_unstemmed | Phytochemicals Mediated Remediation of Neurotoxicity Induced by Heavy Metals |
| title_short | Phytochemicals Mediated Remediation of Neurotoxicity Induced by Heavy Metals |
| title_sort | phytochemicals mediated remediation of neurotoxicity induced by heavy metals |
| url | http://dx.doi.org/10.1155/2015/534769 |
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