Sodium–glucose cotransporter 2 inhibitors ameliorate glutathione cysteine ligase modifier-mediated oxidative stress and subsequent ferroptosis in proximal tubules of diabetic kidney disease

Sodium–glucose cotransporter 2 inhibitors ameliorate glutathione cysteine ligase modifier-mediated oxidative stress and subsequent ferroptosis in proximal tubules of diabetic kidney disease

Objectives Diabetic kidney disease (DKD) is a major cause of end-stage kidney disease. The precise molecular mechanism of ferroptosis, an iron-dependent and non-apoptotic form of regulated cell death, remains poorly understood in DKD, as does the impact of sodium-glucose cotransporter 2 inhibitors (...

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Bibliographic Details
Main Authors: Yi-Chun Tsai, Jiun-Chi Huang, Ping-Shaou Yu, Mei-Chuan Kuo, Ling-Yu Wu, Wei-An Chang, Shang-Jyh Hwang, Ya-Ling Hsu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Redox Report
Subjects:
Sodium–glucose cotransporter 2 inhibitor
proximal tubule
oxidative stress
ferroptosis
glutathione cysteine ligase modifier
diabetic kidney disease
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2025.2528334
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https://www.tandfonline.com/doi/10.1080/13510002.2025.2528334

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