Associations of NF-kappaB and Bax with Apoptosis in Varicose Veins of Women of Different Age Groups
The study aimed at detecting apoptotic endothelial cells (ECs) and smooth muscle cells (SMCs) together with determining expression of NF-kappaB (p105/p50) and Bax in varicose vein walls. Women (n=35) undergoing the excision of varicose veins were divided into 3 groups: younger than 35 years (I), 36–...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/639720 |
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| author | Helle Evi Simovart Andres Arend Jüri Lieberg Marina Aunapuu |
| author_facet | Helle Evi Simovart Andres Arend Jüri Lieberg Marina Aunapuu |
| author_sort | Helle Evi Simovart |
| collection | DOAJ |
| description | The study aimed at detecting apoptotic endothelial cells (ECs) and smooth muscle cells (SMCs) together with determining expression of NF-kappaB (p105/p50) and Bax in varicose vein walls. Women (n=35) undergoing the excision of varicose veins were divided into 3 groups: younger than 35 years (I), 36–50 years (II), and older than 50 years (III). Apoptosis was determined by the TUNEL method, NF-kappaB and Bax expression by immunohistochemistry. The percentage of apoptotic ECs and SMCs in the layers of varicose vein wall increased in groups II and III. NF-kappaB expression had the lowest level in Group II with particularly low level in the media. Contrariwise, Bax expression levels in Group II were increased. The study revealed that in varicose veins ECs and SMCs apoptosis increased with advancing age. If increase in apoptosis during earlier stages of varicosities is probably regulated by intrinsic pathway, then in older patients other signaling pathways may be involved. |
| format | Article |
| id | doaj-art-c6e060e8c8474090adbf94c38144e62c |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-c6e060e8c8474090adbf94c38144e62c2025-02-03T06:43:53ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322011-01-01201110.1155/2011/639720639720Associations of NF-kappaB and Bax with Apoptosis in Varicose Veins of Women of Different Age GroupsHelle Evi Simovart0Andres Arend1Jüri Lieberg2Marina Aunapuu3Department of Anatomy, Biomedicum, University of Tartu, 19 Ravila Street, 50411 Tartu, EstoniaDepartment of Anatomy, Biomedicum, University of Tartu, 19 Ravila Street, 50411 Tartu, EstoniaSurgery Clinic, University of Tartu, 8 L. Puusepa Street, 51014 Tartu, EstoniaDepartment of Anatomy, Biomedicum, University of Tartu, 19 Ravila Street, 50411 Tartu, EstoniaThe study aimed at detecting apoptotic endothelial cells (ECs) and smooth muscle cells (SMCs) together with determining expression of NF-kappaB (p105/p50) and Bax in varicose vein walls. Women (n=35) undergoing the excision of varicose veins were divided into 3 groups: younger than 35 years (I), 36–50 years (II), and older than 50 years (III). Apoptosis was determined by the TUNEL method, NF-kappaB and Bax expression by immunohistochemistry. The percentage of apoptotic ECs and SMCs in the layers of varicose vein wall increased in groups II and III. NF-kappaB expression had the lowest level in Group II with particularly low level in the media. Contrariwise, Bax expression levels in Group II were increased. The study revealed that in varicose veins ECs and SMCs apoptosis increased with advancing age. If increase in apoptosis during earlier stages of varicosities is probably regulated by intrinsic pathway, then in older patients other signaling pathways may be involved.http://dx.doi.org/10.1155/2011/639720 |
| spellingShingle | Helle Evi Simovart Andres Arend Jüri Lieberg Marina Aunapuu Associations of NF-kappaB and Bax with Apoptosis in Varicose Veins of Women of Different Age Groups International Journal of Vascular Medicine |
| title | Associations of NF-kappaB and Bax with Apoptosis in Varicose Veins of Women of Different Age Groups |
| title_full | Associations of NF-kappaB and Bax with Apoptosis in Varicose Veins of Women of Different Age Groups |
| title_fullStr | Associations of NF-kappaB and Bax with Apoptosis in Varicose Veins of Women of Different Age Groups |
| title_full_unstemmed | Associations of NF-kappaB and Bax with Apoptosis in Varicose Veins of Women of Different Age Groups |
| title_short | Associations of NF-kappaB and Bax with Apoptosis in Varicose Veins of Women of Different Age Groups |
| title_sort | associations of nf kappab and bax with apoptosis in varicose veins of women of different age groups |
| url | http://dx.doi.org/10.1155/2011/639720 |
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