Regulatory T cells suppress GM-CSF-producing T helper cells via IL-2 modulation to restrain immunopathology

Regulatory T cells suppress GM-CSF-producing T helper cells via IL-2 modulation to restrain immunopathology

Summary: Regulatory T (Treg) cells are critical for maintaining peripheral tolerance and preventing autoimmunity. Treg cell depletion or dysfunction results in fatal multiorgan inflammation linked to unrestrained effector T cell expansion. Here, we combine in vivo gene targeting and fate-mapping wit...

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Main Authors: Sara Costa-Pereira, Margit Lanzinger, Nicolás Núñez, Juan Villar-Vesga, Myrto Andreadou, Francesco Prisco, Philipp Häne, Elsa Roussel, Sinduya Krishnarajah, Rachel Chanel Lindemann, Laura Oberbichler, Frederike Westermann, André Fonseca Da Silva, Virginia Cecconi, Mirjam Pinzger, Sonia Tugues, Sarah Mundt, Melanie Greter, Donatella De Feo, Burkhard Becher
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725004139
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