Controversies in the Management of Endometrial Cancer

Endometrial cancer (EC) remains the most common malignancy of the female genital tract. The median age at diagnosis is the sixth decade, with abnormal uterine bleeding at the presentation in 90% of the patients. Surgical treatment, including complete hysterectomy, removal of remaining adnexal struct...

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Main Authors: V. Masciullo, G. Amadio, D. Lo Russo, I. Raimondo, A. Giordano, G. Scambia
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Obstetrics and Gynecology International
Online Access:http://dx.doi.org/10.1155/2010/638165
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author V. Masciullo
G. Amadio
D. Lo Russo
I. Raimondo
A. Giordano
G. Scambia
author_facet V. Masciullo
G. Amadio
D. Lo Russo
I. Raimondo
A. Giordano
G. Scambia
author_sort V. Masciullo
collection DOAJ
description Endometrial cancer (EC) remains the most common malignancy of the female genital tract. The median age at diagnosis is the sixth decade, with abnormal uterine bleeding at the presentation in 90% of the patients. Surgical treatment, including complete hysterectomy, removal of remaining adnexal structures, and an appropriate surgical staging, represents the milestone of curative therapy for patients with EC. Adjuvant therapy is necessary in patients at high risk of recurrence. Conservative treatment approaches should be used in selected cases for women with a desire of fertility preservation. This review summarizes the management of EC and discusses current controversies regarding the role of lymphadenectomy and radiotherapy in patients with intermediate-risk tumors confined to the uterus.
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issn 1687-9589
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publishDate 2010-01-01
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series Obstetrics and Gynecology International
spelling doaj-art-c6b715ea10984bdcb3dbdb4cfdae94c12025-02-03T01:10:32ZengWileyObstetrics and Gynecology International1687-95891687-95972010-01-01201010.1155/2010/638165638165Controversies in the Management of Endometrial CancerV. Masciullo0G. Amadio1D. Lo Russo2I. Raimondo3A. Giordano4G. Scambia5Division of Gynecologic Oncology, Catholic University of Sacred Heart, 00168 Rome, ItalyDivision of Gynecologic Oncology, Catholic University of Sacred Heart, 00168 Rome, ItalyDivision of Gynecologic Oncology, Catholic University of Sacred Heart, 00168 Rome, ItalyDivision of Gynecologic Oncology, Catholic University of Sacred Heart, 00168 Rome, ItalyCenter for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USADivision of Gynecologic Oncology, Catholic University of Sacred Heart, 00168 Rome, ItalyEndometrial cancer (EC) remains the most common malignancy of the female genital tract. The median age at diagnosis is the sixth decade, with abnormal uterine bleeding at the presentation in 90% of the patients. Surgical treatment, including complete hysterectomy, removal of remaining adnexal structures, and an appropriate surgical staging, represents the milestone of curative therapy for patients with EC. Adjuvant therapy is necessary in patients at high risk of recurrence. Conservative treatment approaches should be used in selected cases for women with a desire of fertility preservation. This review summarizes the management of EC and discusses current controversies regarding the role of lymphadenectomy and radiotherapy in patients with intermediate-risk tumors confined to the uterus.http://dx.doi.org/10.1155/2010/638165
spellingShingle V. Masciullo
G. Amadio
D. Lo Russo
I. Raimondo
A. Giordano
G. Scambia
Controversies in the Management of Endometrial Cancer
Obstetrics and Gynecology International
title Controversies in the Management of Endometrial Cancer
title_full Controversies in the Management of Endometrial Cancer
title_fullStr Controversies in the Management of Endometrial Cancer
title_full_unstemmed Controversies in the Management of Endometrial Cancer
title_short Controversies in the Management of Endometrial Cancer
title_sort controversies in the management of endometrial cancer
url http://dx.doi.org/10.1155/2010/638165
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AT gamadio controversiesinthemanagementofendometrialcancer
AT dlorusso controversiesinthemanagementofendometrialcancer
AT iraimondo controversiesinthemanagementofendometrialcancer
AT agiordano controversiesinthemanagementofendometrialcancer
AT gscambia controversiesinthemanagementofendometrialcancer