Cyclic Alternating Pattern of EEG Activities and Heart Rate Variability in Parkinson’s Disease Patients during Deep Sleep
Background: Sleep disturbance and autonomic dysfunction are often found in Parkinson’s disease (PD) patients, but little is known about changes in cyclic alternating patterns (CAPs) of electroencephalographic (EEG) activities and heart rate variability (HRV) during deep sleep in P...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2025-03-01
|
| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/JIN/24/3/10.31083/JIN26397 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850067165355442176 |
|---|---|
| author | Zilin Cheng Qi Li Xueliang Zou Zhijun Zhong Qian Ouyang Chunmei Gan Fang Yi Yaxing Luo Yuhao Mao Dongyuan Yao |
| author_facet | Zilin Cheng Qi Li Xueliang Zou Zhijun Zhong Qian Ouyang Chunmei Gan Fang Yi Yaxing Luo Yuhao Mao Dongyuan Yao |
| author_sort | Zilin Cheng |
| collection | DOAJ |
| description | Background: Sleep disturbance and autonomic dysfunction are often found in Parkinson’s disease (PD) patients, but little is known about changes in cyclic alternating patterns (CAPs) of electroencephalographic (EEG) activities and heart rate variability (HRV) during deep sleep in PD patients. Objectives: To investigate changes in EEG activities and HRV during CAPs and non-CAPs (NCAPs) of N3 sleep in PD patients. Methods: Polysomnographic (PSG) examinations were carried out on 18 PD patients and 18 healthy controls, and power spectral analysis of EEG activities and HRV during CAPs and NCAPs (the segment of sleep without CAPs for more than 60 seconds) of N3 sleep were carried out. Results: The percentages of N3 sleep with CAPs and CAP A1, as well as the CAP A1 index in the PD patients, were significantly smaller compared with the healthy controls. In addition, the power of α waves in NCAPs was significantly higher, while the powers of δ waves in Phase A and B of CAP A1 and A3, and NCAPs were significantly smaller. Furthermore, the durations of total δ waves and δ waves with an amplitude ≥75 μV were significantly shorter, and the low frequency (LF) power of HRV during CAPs and the LF/high frequency (HF) HRV ratio during both CAPs and NCAPs were significantly smaller. Conclusions: The changes documented in EEG activities and HRV in PD patients during CAPs and NCAPs of N3 sleep compared with healthy controls suggest that N3 sleep quality and sympathetic function are compromised in PD patients. |
| format | Article |
| id | doaj-art-c6a3c56c7e7f482fb0e42e40f3a58d16 |
| institution | DOAJ |
| issn | 0219-6352 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj-art-c6a3c56c7e7f482fb0e42e40f3a58d162025-08-20T02:48:28ZengIMR PressJournal of Integrative Neuroscience0219-63522025-03-012432639710.31083/JIN26397S0219-6352(24)00902-1Cyclic Alternating Pattern of EEG Activities and Heart Rate Variability in Parkinson’s Disease Patients during Deep SleepZilin Cheng0Qi Li1Xueliang Zou2Zhijun Zhong3Qian Ouyang4Chunmei Gan5Fang Yi6Yaxing Luo7Yuhao Mao8Dongyuan Yao9Neurological Institute of Jiangxi Province and Department of Neurology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, and Xiangya Hospital of Central South University at Jiangxi, 330038 Nanchang, Jiangxi, ChinaNeurological Institute of Jiangxi Province and Department of Neurology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, and Xiangya Hospital of Central South University at Jiangxi, 330038 Nanchang, Jiangxi, ChinaDepartment of Psychology, Jiangxi Mental Hospital, Nanchang University, 330029 Nanchang, Jiangxi, ChinaNeurological Institute of Jiangxi Province and Department of Neurology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, and Xiangya Hospital of Central South University at Jiangxi, 330038 Nanchang, Jiangxi, ChinaNeurological Institute of Jiangxi Province and Department of Neurology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, and Xiangya Hospital of Central South University at Jiangxi, 330038 Nanchang, Jiangxi, ChinaNeurological Institute of Jiangxi Province and Department of Neurology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, and Xiangya Hospital of Central South University at Jiangxi, 330038 Nanchang, Jiangxi, ChinaNeurological Institute of Jiangxi Province and Department of Neurology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, and Xiangya Hospital of Central South University at Jiangxi, 330038 Nanchang, Jiangxi, ChinaNeurological Institute of Jiangxi Province and Department of Neurology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, and Xiangya Hospital of Central South University at Jiangxi, 330038 Nanchang, Jiangxi, ChinaNeurological Institute of Jiangxi Province and Department of Neurology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, and Xiangya Hospital of Central South University at Jiangxi, 330038 Nanchang, Jiangxi, ChinaNeurological Institute of Jiangxi Province and Department of Neurology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, and Xiangya Hospital of Central South University at Jiangxi, 330038 Nanchang, Jiangxi, ChinaBackground: Sleep disturbance and autonomic dysfunction are often found in Parkinson’s disease (PD) patients, but little is known about changes in cyclic alternating patterns (CAPs) of electroencephalographic (EEG) activities and heart rate variability (HRV) during deep sleep in PD patients. Objectives: To investigate changes in EEG activities and HRV during CAPs and non-CAPs (NCAPs) of N3 sleep in PD patients. Methods: Polysomnographic (PSG) examinations were carried out on 18 PD patients and 18 healthy controls, and power spectral analysis of EEG activities and HRV during CAPs and NCAPs (the segment of sleep without CAPs for more than 60 seconds) of N3 sleep were carried out. Results: The percentages of N3 sleep with CAPs and CAP A1, as well as the CAP A1 index in the PD patients, were significantly smaller compared with the healthy controls. In addition, the power of α waves in NCAPs was significantly higher, while the powers of δ waves in Phase A and B of CAP A1 and A3, and NCAPs were significantly smaller. Furthermore, the durations of total δ waves and δ waves with an amplitude ≥75 μV were significantly shorter, and the low frequency (LF) power of HRV during CAPs and the LF/high frequency (HF) HRV ratio during both CAPs and NCAPs were significantly smaller. Conclusions: The changes documented in EEG activities and HRV in PD patients during CAPs and NCAPs of N3 sleep compared with healthy controls suggest that N3 sleep quality and sympathetic function are compromised in PD patients.https://www.imrpress.com/journal/JIN/24/3/10.31083/JIN26397parkinson’s diseasecyclic alternating patternheart rate variabilityα wave intrusionnon-rapid eye movement sleepautonomic nervous system |
| spellingShingle | Zilin Cheng Qi Li Xueliang Zou Zhijun Zhong Qian Ouyang Chunmei Gan Fang Yi Yaxing Luo Yuhao Mao Dongyuan Yao Cyclic Alternating Pattern of EEG Activities and Heart Rate Variability in Parkinson’s Disease Patients during Deep Sleep Journal of Integrative Neuroscience parkinson’s disease cyclic alternating pattern heart rate variability α wave intrusion non-rapid eye movement sleep autonomic nervous system |
| title | Cyclic Alternating Pattern of EEG Activities and Heart Rate Variability in Parkinson’s Disease Patients during Deep Sleep |
| title_full | Cyclic Alternating Pattern of EEG Activities and Heart Rate Variability in Parkinson’s Disease Patients during Deep Sleep |
| title_fullStr | Cyclic Alternating Pattern of EEG Activities and Heart Rate Variability in Parkinson’s Disease Patients during Deep Sleep |
| title_full_unstemmed | Cyclic Alternating Pattern of EEG Activities and Heart Rate Variability in Parkinson’s Disease Patients during Deep Sleep |
| title_short | Cyclic Alternating Pattern of EEG Activities and Heart Rate Variability in Parkinson’s Disease Patients during Deep Sleep |
| title_sort | cyclic alternating pattern of eeg activities and heart rate variability in parkinson s disease patients during deep sleep |
| topic | parkinson’s disease cyclic alternating pattern heart rate variability α wave intrusion non-rapid eye movement sleep autonomic nervous system |
| url | https://www.imrpress.com/journal/JIN/24/3/10.31083/JIN26397 |
| work_keys_str_mv | AT zilincheng cyclicalternatingpatternofeegactivitiesandheartratevariabilityinparkinsonsdiseasepatientsduringdeepsleep AT qili cyclicalternatingpatternofeegactivitiesandheartratevariabilityinparkinsonsdiseasepatientsduringdeepsleep AT xueliangzou cyclicalternatingpatternofeegactivitiesandheartratevariabilityinparkinsonsdiseasepatientsduringdeepsleep AT zhijunzhong cyclicalternatingpatternofeegactivitiesandheartratevariabilityinparkinsonsdiseasepatientsduringdeepsleep AT qianouyang cyclicalternatingpatternofeegactivitiesandheartratevariabilityinparkinsonsdiseasepatientsduringdeepsleep AT chunmeigan cyclicalternatingpatternofeegactivitiesandheartratevariabilityinparkinsonsdiseasepatientsduringdeepsleep AT fangyi cyclicalternatingpatternofeegactivitiesandheartratevariabilityinparkinsonsdiseasepatientsduringdeepsleep AT yaxingluo cyclicalternatingpatternofeegactivitiesandheartratevariabilityinparkinsonsdiseasepatientsduringdeepsleep AT yuhaomao cyclicalternatingpatternofeegactivitiesandheartratevariabilityinparkinsonsdiseasepatientsduringdeepsleep AT dongyuanyao cyclicalternatingpatternofeegactivitiesandheartratevariabilityinparkinsonsdiseasepatientsduringdeepsleep |