E2F1/CDK5/DRP1 axis mediates microglial mitochondrial division and autophagy in the pathogenesis of cerebral ischemia‐reperfusion injury

E2F1/CDK5/DRP1 axis mediates microglial mitochondrial division and autophagy in the pathogenesis of cerebral ischemia‐reperfusion injury

Abstract Background The integrity of brain function is at stake due to cerebral ischemia‐reperfusion injury (CIRI), which encompasses mitochondrial dysfunction, autophagy, and neuroinflammation. The role of E2F1 in mediating these processes in microglia during CIRI remains unclear. Methods A CIRI mo...

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Bibliographic Details
Main Authors: Ya‐Jing Yuan, Tingting Chen, Yan‐Ling Yang, Hao‐Nan Han, Li‐Ming Xu
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Clinical and Translational Medicine
Subjects:
CDK5
cerebral ischemia‐reperfusion
DRP1
E2F1
microglia
mitochondrial division
Online Access:https://doi.org/10.1002/ctm2.70197
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