CBD-conjugated BMP-inhibiting exosomes on collagen scaffold dual-target Achilles tendon repair: Synergistic regeneration and heterotopic ossification prevention

CBD-conjugated BMP-inhibiting exosomes on collagen scaffold dual-target Achilles tendon repair: Synergistic regeneration and heterotopic ossification prevention

Tendon injuries in the aging population are often complicated by heterotopic ossification (HO), hindering functional recovery. Exosomes from tendon stem/progenitor cells (TSPCs) promote regeneration but may also induce osteogenesis, contributing to HO. Preconditioning with the BMP inhibitor LDN19318...

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Bibliographic Details
Main Authors: Yan Xu, Jiaqiang Huang, Yingjie Mai, Zhiyuan Zhang, Siqi Li, Haofeng Lin, Fuxin Wei, Yang Chen
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Materials Today Bio
Subjects:
Achilles tendon repair
Tissue-engineered exosomes
Heterotopic ossification
BMP signaling
3D scaffold
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425003503
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