Human mitochondrial leucyl tRNA synthetase can suppress non cognate pathogenic mt‐tRNA mutations

Human mitochondrial leucyl tRNA synthetase can suppress non cognate pathogenic mt‐tRNA mutations

Abstract Disorders of the mitochondrial genome cause a wide spectrum of disease, these present mainly as neurological and/or muscle related pathologies. Due to the intractability of the human mitochondrial genome there are currently no effective treatments for these disorders. The majority of the pa...

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Main Authors: Hue Tran Hornig‐Do, Arianna Montanari, Agata Rozanska, Helen A Tuppen, Abdulraheem A Almalki, Dyg P Abg‐Kamaludin, Laura Frontali, Silvia Francisci, Robert N Lightowlers, Zofia M Chrzanowska‐Lightowlers
Format: Article
Language:English
Published: Springer Nature 2014-01-01
Series:EMBO Molecular Medicine
Subjects:
aminoacyl tRNA synthetase
disease
mitochondria
protein synthesis
therapy
Online Access:https://doi.org/10.1002/emmm.201303202
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https://doi.org/10.1002/emmm.201303202

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