Reticuloendothelial system blockade does not enhance siRNA-LNP circulation or tumor accumulation in mice

Reticuloendothelial system blockade does not enhance siRNA-LNP circulation or tumor accumulation in mice

One of the biggest challenges for siRNA-based therapeutics is intracellular delivery into the target cell, which can be facilitated by encapsulating siRNA in lipid nanoparticles (LNPs). In this study, we formulated D-Lin-MC3-DMA-LNPs encapsulating siRNA against the androgen receptor (AR), a key driv...

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Bibliographic Details
Main Authors: Pol Escudé Martinez de Castilla, Mariona Estapé Senti, Sigrun Erkens, Wytske M. van Weerden, Sander A.A. Kooijmans, Marcel H. Fens, Pieter Vader, Raymond M. Schiffelers
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:International Journal of Pharmaceutics: X
Subjects:
siRNA-lipid nanoparticles
Reticuloendothelial system (RES)
Tissue distribution
Pharmacokinetics
Liposomes
Dextran sulfate
Online Access:http://www.sciencedirect.com/science/article/pii/S259015672500009X
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