Effect of epileptiform discharges and hippocampal volume on cognitive dysfunction following clipping of ruptured aneurysms in the anterior circulation
IntroductionCognitive dysfunction after aneurysmal subarachnoid hemorrhage (aSAH) remains unclear due to various neurological impairments. This study aimed to evaluate the changes in hippocampal volume, cognitive function, and interictal epileptiform discharges after clipping in patients with aSAH o...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2025.1428311/full |
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| author | Kunitoshi Otsuka Shigeki Sunaga Hiroyuki Jimbo Yoshinori Suzuki Michihiro Kohno |
| author_facet | Kunitoshi Otsuka Shigeki Sunaga Hiroyuki Jimbo Yoshinori Suzuki Michihiro Kohno |
| author_sort | Kunitoshi Otsuka |
| collection | DOAJ |
| description | IntroductionCognitive dysfunction after aneurysmal subarachnoid hemorrhage (aSAH) remains unclear due to various neurological impairments. This study aimed to evaluate the changes in hippocampal volume, cognitive function, and interictal epileptiform discharges after clipping in patients with aSAH of anterior circulation.MethodsPatients with modified Rankin Scale scores of 0–3 points who underwent clipping were evaluated. Aneurysmal locations were classified as middle cerebral artery (MCA), internal carotid artery (ICA), and anterior cerebral artery (ACA). Surgery was performed using the transsylvian approach or interhemispheric approach. Hippocampal volume measurement, neuropsychological assessments, and interictal electroencephalogram evaluations were performed postoperatively at the subacute phase. Epileptiform discharges were assessed using the spike index (SI).ResultsWe included 60 patients (23 men, 37 women; median age, 57.4 years). Aneurysmal locations were found in the MCA, ICA, and ACA in 23, 19, and 18 patients, respectively. The postoperative hippocampal volume was significantly reduced on the clipping approach side in the MCA and ICA groups (MCA, p < .001; ICA, p < .001). There was no correlation between hippocampal volume and cognitive function. A significant difference was noted in elevated SI on the approach side of the MCA (p < .001), ICA (p < .001), and ACA (p < .001) in the transsylvian approach group. The elevated SI on the left approach side showed significant differences in some neuropsychological assessments (performance intellectual quotient, p = .028; perceptual organization, p = .045; working memory, p = .003).DiscussionCognitive dysfunction in the subacute phase after clipping for aSAH was not correlated with hippocampal volume reduction but was correlated with interictal epileptiform discharges. |
| format | Article |
| id | doaj-art-c6342b11ee5948d39d92910d17cfe075 |
| institution | Kabale University |
| issn | 2296-875X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Surgery |
| spelling | doaj-art-c6342b11ee5948d39d92910d17cfe0752025-01-20T07:19:53ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2025-01-011210.3389/fsurg.2025.14283111428311Effect of epileptiform discharges and hippocampal volume on cognitive dysfunction following clipping of ruptured aneurysms in the anterior circulationKunitoshi Otsuka0Shigeki Sunaga1Hiroyuki Jimbo2Yoshinori Suzuki3Michihiro Kohno4Department of Neurosurgery, Tokyo Medical University Hachioji Medical Center, Tokyo, JapanDepartment of Neurosurgery, Tokyo Medical University Hachioji Medical Center, Tokyo, JapanDepartment of Neurosurgery, Tokyo Medical University Hachioji Medical Center, Tokyo, JapanDepartment of Clinical Radiology, Tokyo Medical University Hachioji Medical Center, Tokyo, JapanDepartment of Neurosurgery, Tokyo Medical University Hospital, Tokyo, JapanIntroductionCognitive dysfunction after aneurysmal subarachnoid hemorrhage (aSAH) remains unclear due to various neurological impairments. This study aimed to evaluate the changes in hippocampal volume, cognitive function, and interictal epileptiform discharges after clipping in patients with aSAH of anterior circulation.MethodsPatients with modified Rankin Scale scores of 0–3 points who underwent clipping were evaluated. Aneurysmal locations were classified as middle cerebral artery (MCA), internal carotid artery (ICA), and anterior cerebral artery (ACA). Surgery was performed using the transsylvian approach or interhemispheric approach. Hippocampal volume measurement, neuropsychological assessments, and interictal electroencephalogram evaluations were performed postoperatively at the subacute phase. Epileptiform discharges were assessed using the spike index (SI).ResultsWe included 60 patients (23 men, 37 women; median age, 57.4 years). Aneurysmal locations were found in the MCA, ICA, and ACA in 23, 19, and 18 patients, respectively. The postoperative hippocampal volume was significantly reduced on the clipping approach side in the MCA and ICA groups (MCA, p < .001; ICA, p < .001). There was no correlation between hippocampal volume and cognitive function. A significant difference was noted in elevated SI on the approach side of the MCA (p < .001), ICA (p < .001), and ACA (p < .001) in the transsylvian approach group. The elevated SI on the left approach side showed significant differences in some neuropsychological assessments (performance intellectual quotient, p = .028; perceptual organization, p = .045; working memory, p = .003).DiscussionCognitive dysfunction in the subacute phase after clipping for aSAH was not correlated with hippocampal volume reduction but was correlated with interictal epileptiform discharges.https://www.frontiersin.org/articles/10.3389/fsurg.2025.1428311/fullaneurysmal clippingcognitive dysfunctioninterictal epileptiform dischargeshippocampal volumespike indexsubarachnoid hemorrhage |
| spellingShingle | Kunitoshi Otsuka Shigeki Sunaga Hiroyuki Jimbo Yoshinori Suzuki Michihiro Kohno Effect of epileptiform discharges and hippocampal volume on cognitive dysfunction following clipping of ruptured aneurysms in the anterior circulation Frontiers in Surgery aneurysmal clipping cognitive dysfunction interictal epileptiform discharges hippocampal volume spike index subarachnoid hemorrhage |
| title | Effect of epileptiform discharges and hippocampal volume on cognitive dysfunction following clipping of ruptured aneurysms in the anterior circulation |
| title_full | Effect of epileptiform discharges and hippocampal volume on cognitive dysfunction following clipping of ruptured aneurysms in the anterior circulation |
| title_fullStr | Effect of epileptiform discharges and hippocampal volume on cognitive dysfunction following clipping of ruptured aneurysms in the anterior circulation |
| title_full_unstemmed | Effect of epileptiform discharges and hippocampal volume on cognitive dysfunction following clipping of ruptured aneurysms in the anterior circulation |
| title_short | Effect of epileptiform discharges and hippocampal volume on cognitive dysfunction following clipping of ruptured aneurysms in the anterior circulation |
| title_sort | effect of epileptiform discharges and hippocampal volume on cognitive dysfunction following clipping of ruptured aneurysms in the anterior circulation |
| topic | aneurysmal clipping cognitive dysfunction interictal epileptiform discharges hippocampal volume spike index subarachnoid hemorrhage |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2025.1428311/full |
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