Collapsin Response Mediator Protein 2 (CRMP2) Modulates Mitochondrial Oxidative Metabolism in Knock-In AD Mouse Model

Collapsin Response Mediator Protein 2 (CRMP2) Modulates Mitochondrial Oxidative Metabolism in Knock-In AD Mouse Model

We explored how the phosphorylation state of collapsin response mediator protein 2 (CRMP2) influences mitochondrial functions in cultured cortical neurons and cortical synaptic mitochondria isolated from APP-SAA KI mice, a knock-in APP mouse model of Alzheimer’s disease (AD). CRMP2 phosphorylation w...

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Bibliographic Details
Main Authors: Tatiana Brustovetsky, Rajesh Khanna, Nickolay Brustovetsky
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Cells
Subjects:
CRMP2
Alzheimer’s disease
cortical neurons
mitochondrial oxidative metabolism
mitochondrial ROS production
adenine nucleotide translocase
Online Access:https://www.mdpi.com/2073-4409/14/9/647
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