Inhibition of tumor-intrinsic NAT10 enhances antitumor immunity by triggering type I interferon response via MYC/CDK2/DNMT1 pathway

Inhibition of tumor-intrinsic NAT10 enhances antitumor immunity by triggering type I interferon response via MYC/CDK2/DNMT1 pathway

Abstract Posttranscriptional modifications are involved in cancer progression. However, the function and regulatory mechanism of mRNA acetylation modification remains largely unknown. Here, we discover an unexpected role of N4-acetylcytidine (ac4C) RNA acetyltransferase NAT10 in reshaping the tumor...

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Main Authors: Wan-cheng Liu, Yi-hong Wei, Jin-feng Chen, Xiang-ling Xing, He-xiao Jia, Xin-yu Yang, Ying-jian Huang, Xiao-min Liu, Ke Xiao, Xiao-dong Guo, Can Can, A-min Zhang, Na He, Hai-lei Zhang, Dao-xin Ma
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60293-4
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