In silico identification and characterisation of pathogenic genetic variants (nsSNPs) in the eukaryotic initiation factors eIF2 and eIF2B affecting miRNA binding sites

In silico identification and characterisation of pathogenic genetic variants (nsSNPs) in the eukaryotic initiation factors eIF2 and eIF2B affecting miRNA binding sites

Abstract Background The eukaryotic translation initiation factors (eIF2 and eIF2B) are known to play a regulatory role in translation initiation. Studies have indicated that several missense mutations in both eIF2 and eIF2B subunits can lead to severe neurological diseases and cancer. In the current...

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Bibliographic Details
Main Authors: Pavan K. Madasu, V. Lokesh Subrahmanyam, Thyageshwar Chandran
Format: Article
Language:English
Published: SpringerOpen 2024-10-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Eukaryotic initiation factors
3′ Untranslated regions
Gene ontology
Molecular docking
Neurological disorders
Cancer
Online Access:https://doi.org/10.1186/s43042-024-00596-1
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https://doi.org/10.1186/s43042-024-00596-1

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