<i>Helicobacter pylori</i> HP0135 Is a Small Lipoprotein That Has a Role in Outer Membrane Stability
<i>Helicobacter pylori</i> is a Gram-negative bacterium and human pathogen that is linked to various gastric diseases, including peptic ulcer disease, chronic gastritis, and gastric cancer. The filament of the <i>H. pylori</i> flagellum is surrounded by a membranous sheath th...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/2/204 |
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| Summary: | <i>Helicobacter pylori</i> is a Gram-negative bacterium and human pathogen that is linked to various gastric diseases, including peptic ulcer disease, chronic gastritis, and gastric cancer. The filament of the <i>H. pylori</i> flagellum is surrounded by a membranous sheath that is contiguous with the outer membrane. Proteomic analysis of isolated sheathed flagella from <i>H. pylori</i> B128 identified the lipoprotein HP0135 as a potential component of the flagellar sheath. HP0135 is a small protein, with the mature HP0135 lipoprotein only 28 amino acid residues in length. Deletion of <i>hp0135</i> in <i>H. pylori</i> B128 resulted in morphological abnormalities that included extensive formation of outer membrane vesicles and increased frequency of mini-cells. Introducing a plasmid-borne copy of <i>hp0135</i> into the <i>H. pylori</i> Δ<i>hp0135</i> mutant suppressed the morphological abnormalities. The phenotype of the Δ<i>hp0135</i> mutant suggests HP0135 has roles in stabilizing the cell envelope and cell division. |
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| ISSN: | 1420-3049 |