β-Glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects
Particle size and surface properties are crucial for lymphatic drainage (LN), dendritic cell (DC) uptake, DC maturation, and antigen cross-presentation induced by nanovaccine injection, which lead to an effective cell-mediated immune response. However, the manner in which the particle size and surfa...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Pharmaceutical Analysis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177924000509 |
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| author | Wen Guo Xinyue Zhang Long Wan Zhiqi Wang Meiqi Han Ziwei Yan Jia Li Ruizhu Deng Shenglong Li Yuling Mao Siling Wang |
| author_facet | Wen Guo Xinyue Zhang Long Wan Zhiqi Wang Meiqi Han Ziwei Yan Jia Li Ruizhu Deng Shenglong Li Yuling Mao Siling Wang |
| author_sort | Wen Guo |
| collection | DOAJ |
| description | Particle size and surface properties are crucial for lymphatic drainage (LN), dendritic cell (DC) uptake, DC maturation, and antigen cross-presentation induced by nanovaccine injection, which lead to an effective cell-mediated immune response. However, the manner in which the particle size and surface properties of vaccine carriers such as mesoporous silica nanoparticles (MSNs) affect this immune response is unknown. We prepared 50, 100, and 200 nm of MSNs that adsorbed ovalbumin antigen (OVA) while modifying β-glucan to enhance immunogenicity. The results revealed that these MSNs with different particle sizes were just as efficient in vitro, and MSNs with β-glucan modification demonstrated higher efficacy. However, the in vivo results indicated that MSNs with smaller particle sizes have stronger lymphatic targeting efficiency and a greater ability to promote the maturation of DCs. The results also indicate that β-glucan-modified MSN, with a particle size of ∼100 nm, has a great potential as a vaccine delivery vehicle and immune adjuvant and offers a novel approach for the delivery of multiple therapeutic agents that target other lymph-mediated diseases. |
| format | Article |
| id | doaj-art-c5bbe9b067594263b5e8ef503b4a50a9 |
| institution | Kabale University |
| issn | 2095-1779 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmaceutical Analysis |
| spelling | doaj-art-c5bbe9b067594263b5e8ef503b4a50a92025-01-30T05:13:57ZengElsevierJournal of Pharmaceutical Analysis2095-17792024-12-011412100953β-Glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effectsWen Guo0Xinyue Zhang1Long Wan2Zhiqi Wang3Meiqi Han4Ziwei Yan5Jia Li6Ruizhu Deng7Shenglong Li8Yuling Mao9Siling Wang10Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmacy, The First Hospital of China Medical University, Shenyang, 110001, China; School of Pharmacy, China Medical University, Shenyang, 110122, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Microbiology and Biochemical Pharmacy, School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaSecond Ward of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, 110042, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China; Corresponding author.Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China; Corresponding author.Particle size and surface properties are crucial for lymphatic drainage (LN), dendritic cell (DC) uptake, DC maturation, and antigen cross-presentation induced by nanovaccine injection, which lead to an effective cell-mediated immune response. However, the manner in which the particle size and surface properties of vaccine carriers such as mesoporous silica nanoparticles (MSNs) affect this immune response is unknown. We prepared 50, 100, and 200 nm of MSNs that adsorbed ovalbumin antigen (OVA) while modifying β-glucan to enhance immunogenicity. The results revealed that these MSNs with different particle sizes were just as efficient in vitro, and MSNs with β-glucan modification demonstrated higher efficacy. However, the in vivo results indicated that MSNs with smaller particle sizes have stronger lymphatic targeting efficiency and a greater ability to promote the maturation of DCs. The results also indicate that β-glucan-modified MSN, with a particle size of ∼100 nm, has a great potential as a vaccine delivery vehicle and immune adjuvant and offers a novel approach for the delivery of multiple therapeutic agents that target other lymph-mediated diseases.http://www.sciencedirect.com/science/article/pii/S2095177924000509Smart nanoparticlesImmunomodulatory nano-vaccineLymph node targetingMesoporous silica nanoparticlesDendritic cells mature |
| spellingShingle | Wen Guo Xinyue Zhang Long Wan Zhiqi Wang Meiqi Han Ziwei Yan Jia Li Ruizhu Deng Shenglong Li Yuling Mao Siling Wang β-Glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects Journal of Pharmaceutical Analysis Smart nanoparticles Immunomodulatory nano-vaccine Lymph node targeting Mesoporous silica nanoparticles Dendritic cells mature |
| title | β-Glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects |
| title_full | β-Glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects |
| title_fullStr | β-Glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects |
| title_full_unstemmed | β-Glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects |
| title_short | β-Glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects |
| title_sort | β glucan modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects |
| topic | Smart nanoparticles Immunomodulatory nano-vaccine Lymph node targeting Mesoporous silica nanoparticles Dendritic cells mature |
| url | http://www.sciencedirect.com/science/article/pii/S2095177924000509 |
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