The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography
Mercaptopurine and its derivatives are used in the treatment of leukemia. To estimate their lipophilicity, a simple and novel thin layer chromatography method was developed. The mobile phase was the mixture of acetonitrile and water. The acetonitrile content varied by 5% from 50% to 80%. The linear...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/419194 |
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| author | Andrzej Czyrski Bartłomiej Kupczyk |
| author_facet | Andrzej Czyrski Bartłomiej Kupczyk |
| author_sort | Andrzej Czyrski |
| collection | DOAJ |
| description | Mercaptopurine and its derivatives are used in the treatment of leukemia. To estimate their lipophilicity, a simple and novel thin layer chromatography method was developed. The mobile phase was the mixture of acetonitrile and water. The acetonitrile content varied by 5% from 50% to 80%. The linear relationship between log𝑃 and 𝑅𝑚0 for substances with known lipophilicity was found. The lipophilicity of purine derivatives was worked out from the calibration curve. The most lipohilic compound was methylazathioprine (0.64). |
| format | Article |
| id | doaj-art-c5bac4ca0c9e4520a90b4c3c0619b304 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-c5bac4ca0c9e4520a90b4c3c0619b3042025-02-03T01:10:05ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/419194419194The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer ChromatographyAndrzej Czyrski0Bartłomiej Kupczyk1Department of Physical Pharmacy and Pharmacokinetics, Poznań University of Medical Sciences, 6 Świecickiego Street, 60-781 Poznań, PolandDepartment of Physical Pharmacy and Pharmacokinetics, Poznań University of Medical Sciences, 6 Świecickiego Street, 60-781 Poznań, PolandMercaptopurine and its derivatives are used in the treatment of leukemia. To estimate their lipophilicity, a simple and novel thin layer chromatography method was developed. The mobile phase was the mixture of acetonitrile and water. The acetonitrile content varied by 5% from 50% to 80%. The linear relationship between log𝑃 and 𝑅𝑚0 for substances with known lipophilicity was found. The lipophilicity of purine derivatives was worked out from the calibration curve. The most lipohilic compound was methylazathioprine (0.64).http://dx.doi.org/10.1155/2013/419194 |
| spellingShingle | Andrzej Czyrski Bartłomiej Kupczyk The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography Journal of Chemistry |
| title | The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography |
| title_full | The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography |
| title_fullStr | The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography |
| title_full_unstemmed | The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography |
| title_short | The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography |
| title_sort | determination of partition coefficient of 6 mercaptopurine derivatives by thin layer chromatography |
| url | http://dx.doi.org/10.1155/2013/419194 |
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