A Tumultuous Course of Exogenous Testosterone by a Bodybuilder Causing a Catastrophic Hypercoagulable State in the Surgical Intensive Care Unit
Present literature demonstrates an equivocal relationship between testosterone and thrombogenicity. Herein, we describe a case in which a patient used an unspecified amount and duration of exogenous testosterone injections, subsequently developing thrombotic events in his: right radial artery, right...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/3097865 |
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| _version_ | 1832556089149751296 |
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| author | Kevin Lee Sophia Toraby Robert Cotterman Babatunde Oriowo John Fish |
| author_facet | Kevin Lee Sophia Toraby Robert Cotterman Babatunde Oriowo John Fish |
| author_sort | Kevin Lee |
| collection | DOAJ |
| description | Present literature demonstrates an equivocal relationship between testosterone and thrombogenicity. Herein, we describe a case in which a patient used an unspecified amount and duration of exogenous testosterone injections, subsequently developing thrombotic events in his: right radial artery, right iliac artery, superficial femoral artery, splenic artery and a bilateral lower lobe pulmonary embolism. As a result, clinicians should consider exogenous testosterone use as a potential risk factor when the etiology of a patient’s thrombotic events are not clear. We also completed a literature review of the molecular mechanisms in which testosterone can increase the clot burden through an increases human platelet thromboxane A2 receptor density and an increase in erythropoiesis. |
| format | Article |
| id | doaj-art-c5b990cfc0b14c7f98829260398bd9e7 |
| institution | Kabale University |
| issn | 2090-6986 2090-6994 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Vascular Medicine |
| spelling | doaj-art-c5b990cfc0b14c7f98829260398bd9e72025-02-03T05:46:30ZengWileyCase Reports in Vascular Medicine2090-69862090-69942019-01-01201910.1155/2019/30978653097865A Tumultuous Course of Exogenous Testosterone by a Bodybuilder Causing a Catastrophic Hypercoagulable State in the Surgical Intensive Care UnitKevin Lee0Sophia Toraby1Robert Cotterman2Babatunde Oriowo3John Fish4Department of Anesthesiology, The University of Toledo Medical Center, Toledo, OH, USADepartment of Surgery, The University of Toledo Medical Center, Toledo, OH, USADepartment of Surgery, The University of Toledo Medical Center, Toledo, OH, USADepartment of Surgery, The University of Toledo Medical Center, Toledo, OH, USADepartment of Surgery, The University of Toledo Medical Center, Toledo, OH, USAPresent literature demonstrates an equivocal relationship between testosterone and thrombogenicity. Herein, we describe a case in which a patient used an unspecified amount and duration of exogenous testosterone injections, subsequently developing thrombotic events in his: right radial artery, right iliac artery, superficial femoral artery, splenic artery and a bilateral lower lobe pulmonary embolism. As a result, clinicians should consider exogenous testosterone use as a potential risk factor when the etiology of a patient’s thrombotic events are not clear. We also completed a literature review of the molecular mechanisms in which testosterone can increase the clot burden through an increases human platelet thromboxane A2 receptor density and an increase in erythropoiesis.http://dx.doi.org/10.1155/2019/3097865 |
| spellingShingle | Kevin Lee Sophia Toraby Robert Cotterman Babatunde Oriowo John Fish A Tumultuous Course of Exogenous Testosterone by a Bodybuilder Causing a Catastrophic Hypercoagulable State in the Surgical Intensive Care Unit Case Reports in Vascular Medicine |
| title | A Tumultuous Course of Exogenous Testosterone by a Bodybuilder Causing a Catastrophic Hypercoagulable State in the Surgical Intensive Care Unit |
| title_full | A Tumultuous Course of Exogenous Testosterone by a Bodybuilder Causing a Catastrophic Hypercoagulable State in the Surgical Intensive Care Unit |
| title_fullStr | A Tumultuous Course of Exogenous Testosterone by a Bodybuilder Causing a Catastrophic Hypercoagulable State in the Surgical Intensive Care Unit |
| title_full_unstemmed | A Tumultuous Course of Exogenous Testosterone by a Bodybuilder Causing a Catastrophic Hypercoagulable State in the Surgical Intensive Care Unit |
| title_short | A Tumultuous Course of Exogenous Testosterone by a Bodybuilder Causing a Catastrophic Hypercoagulable State in the Surgical Intensive Care Unit |
| title_sort | tumultuous course of exogenous testosterone by a bodybuilder causing a catastrophic hypercoagulable state in the surgical intensive care unit |
| url | http://dx.doi.org/10.1155/2019/3097865 |
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