Quantitative and Kinetic Proteomics Reveal ApoE Isoform-dependent Proteostasis Adaptations in Mouse Brain.

Quantitative and Kinetic Proteomics Reveal ApoE Isoform-dependent Proteostasis Adaptations in Mouse Brain.

Apolipoprotein E (ApoE) polymorphisms modify the risk of Alzheimer's disease with ApoE4 strongly increasing and ApoE2 modestly decreasing risk relative to the control ApoE3. To investigate how ApoE isoforms alter risk, we measured changes in proteome homeostasis in transgenic mice expressing a...

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Main Authors: Nathan R Zuniga, Noah E Earls, Ariel E A Denos, Jared M Elison, Benjamin S Jones, Ethan G Smith, Noah G Moran, Katie L Broce, Gerome M Romero, Chad D Hyer, Kimberly B Wagstaff, Haifa M Almughamsi, Mark K Transtrum, John C Price
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1012407
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https://doi.org/10.1371/journal.pcbi.1012407

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