Role of the multiple telomeric repeat arrays in integration, persistence, and efficacy of the commercial CVI988 vaccine

Role of the multiple telomeric repeat arrays in integration, persistence, and efficacy of the commercial CVI988 vaccine

ABSTRACT Marek’s disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes fatal T cell lymphomas in chickens. Oncogenic MDV strains can integrate their genome into the host telomeres of latently infected and tumor cells. This integration process is facilitated by telomeric repeat array...

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Bibliographic Details
Main Authors: Luca D. Bertzbach, Yu You, Tereza Vychodil, Ahmed Kheimar, Lisa Kossak, Mohammad A. Sabsabi, Andelé M. Conradie, Benedikt B. Kaufer
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mSphere
Subjects:
herpesvirus
CVI988
Rispens
genome integration
MDV vaccine
telomeres
Online Access:https://journals.asm.org/doi/10.1128/msphere.00142-25
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https://journals.asm.org/doi/10.1128/msphere.00142-25

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