Perivascular space and white matter hyperintensities in Alzheimer’s disease: associations with disease progression and cognitive function

Perivascular space and white matter hyperintensities in Alzheimer’s disease: associations with disease progression and cognitive function

Abstract Background Alzheimer’s disease (AD) is the leading cause of dementia, characterized by the accumulation of amyloid-beta (Aβ) and neurofibrillary tangles. Recent studies emphasize the role of vascular factors, including the glymphatic system, in AD pathogenesis, particularly in Aβ clearance....

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Main Authors: Philine Marie Schirge, Robert Perneczky, Toshiaki Taoka, Adriana L. Ruiz-Rizzo, Ersin Ersoezlue, Robert Forbrig, Selim Guersel, Carolin Kurz, Matthias Brendel, Julian Hellmann-Regen, Josef Priller, Anja Schneider, Frank Jessen, Emrah Düzel, Katharina Buerger, Stefan Teipel, Christoph Laske, Oliver Peters, Eike Spruth, Klaus Fliessbach, Ayda Rostamzadeh, Wenzel Glanz, Daniel Janowitz, Ingo Kilimann, Sebastian Sodenkamp, Michael Ewers, Boris-Stephan Rauchmann
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Alzheimer’s Research & Therapy
Subjects:
Perivascular space
Diffusion tensor imaging
Amyloid-beta
Cognitive decline
Alzheimer's disease
Dementia
Online Access:https://doi.org/10.1186/s13195-025-01707-9
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