Non-invasive breath testing to detect colorectal cancer: protocol for a multicentre, case–control development and validation study (COBRA2 study)

Non-invasive breath testing to detect colorectal cancer: protocol for a multicentre, case–control development and validation study (COBRA2 study)

Abstract Background Colorectal cancer (CRC) is the fourth most common cancer in the United Kingdom. The five-year survival rate from CRC is only 10% when discovered at a late stage, but can exceed 90% if diagnosed early. Symptoms related to CRC can be non-specific, and therefore the decision to refe...

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Main Authors: Michael G. Fadel, James Murray, Georgia Woodfield, Ilaria Belluomo, Ivan Laponogov, Aaron Parker, Valerio Converso, James K. Ellis, Pete Wheatstone, Julie Hepburn, Chris Groves, Kevin Monahan, Brian P. Saunders, Patrik Španěl, Kirill Veselkov, Amanda J. Cross, Christos Kontovounisios, Linda D. Sharples, George B. Hanna, COBRA2 Collaborators
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Breath test
Volatile organic compounds
Biomarkers
Detection
Diagnostic model
Online Access:https://doi.org/10.1186/s12885-025-14520-2
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https://doi.org/10.1186/s12885-025-14520-2

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