Circulating tumor DNA strongly predicts efficacy of chemotherapy plus immune checkpoint inhibitors in patients with advanced gastro-esophageal adenocarcinoma

Circulating tumor DNA strongly predicts efficacy of chemotherapy plus immune checkpoint inhibitors in patients with advanced gastro-esophageal adenocarcinoma

Abstract Background Efficacy of 2nd line treatment in advanced gastric or gastro-esophageal junction (GEJ) adenocarcinoma remains limited with no identified strong predictor of treatment efficacy. We evaluated the prognostic value of circulating tumor DNA (ctDNA) in predicting the efficacy of immune...

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Main Authors: David Tougeron, Christophe Louvet, Jérôme Desramé, Ludovic Evesque, Antoine Angelergues, Aurélien Carnot, Gilles Breysacher, Aziz Zaanan, Nicolas Etchepare, May Mabro, Laure Kaluzinski, Caroline Petorin, Benoist Chibaudel, Thomas Aparicio, Anaïs Bodere, Yves Rinaldi, Karine Le Malicot, Jean-François Emile, Côme Lepage, Aurélia Baures, Hanane Djamai, Valérie Taly, Pierre Laurent-Puig
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-00867-x
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https://doi.org/10.1038/s43856-025-00867-x

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