T14diLys/DOPE Liposomes: An Innovative Option for siRNA-Based Gene Knockdown?

T14diLys/DOPE Liposomes: An Innovative Option for siRNA-Based Gene Knockdown?

Background/Objectives: Bringing small interfering RNA (siRNA) into the cell cytosol to achieve specific gene silencing is an attractive but also very challenging option for improved therapies. The first step for successful siRNA delivery is the complexation with a permanent cationic or ionizable com...

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Bibliographic Details
Main Authors: Sophie Meinhard, Frank Erdmann, Henrike Lucas, Maria Krabbes, Stephanie Krüger, Christian Wölk, Karsten Mäder
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceutics
Subjects:
siRNA
lipoplex
ionizable lipid
T14diLys
extrusion
transfection
Online Access:https://www.mdpi.com/1999-4923/17/1/25
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